Publications
Medical Congresses
- December 2020
SIG-001
First-in-Human Phase 1/2 Clinical Trial of SIG-001, an Innovative Shielded Cell Therapy Platform, for Hemophilia A, ASH 2020, Abstract - July 2020
SIG-001
SIG-001 for Hemophilia A: Preclinical Safety and Efficacy Studies Conducted in Mice and Non-Human Primates, ISTH 2020, Abstract - May 2020
SLTx Platform
Optimization of Shielded Encapsulated Cell Therapy for Hemophilia and Beyond, ASGCT 2020, Abstract - February 2020
SIG-009
Correcting FVII Deficiency Using Coagulation Factors Produced in Vivo by Encapsulated Engineered Allogeneic Cells, EAHAD 2020, Abstract - February 2020
SIG-005
Preclinical Development of SIG-005 for Treatment of MPS1, WORLD Symposium 2020, Abstract - February 2020
SIG-007
Preclinical Development of SIG-007 for Treatment of Fabry Disease, WORLD Symposium 2020, Abstract - December 2019
SIG-001
Correcting Rare Blood Disorders Using Coagulation Factors Produced in vivo by Shielded Living Therapeutics™ Products, ASH 2019, Abstract
Peer Reviewed Publications
- March 30, 2020
A Retrievable Implant for the Long-Term Encapsulation and Survival of Therapeutic Xenogeneic Cells, Nature Biomedical Engineering - Winter 2019-2020
Hemophilia Federation of America's 2019-20 Special Dateline Federation Magazine: Emerging Therapies, Hemophilia Federation of America - August 13, 2018
Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques, Nature Biomedical Engineering - July 30, 2018
Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer, Nature Biomedical Engineering - April 12, 2018
Evolving Industry Partnerships and Investments in Cell and Gene Therapies, Cell Stem Cell - April 2, 2018
Future Therapies Using Implanted Engineered Cells as Protein Factories, PharmTech - December 11, 2018
Coated glucose sensors dodge recalibration, Nature Biomedical Engineering - March 20, 2017
Colony stimulating factor-1 receptor is a central component ofthe foreign body response tobiomaterial implants in rodents and non-human primates, Nature Materials - January 25, 2016
Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice, Nature Medicine - January 25, 2016
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates, Nature Biotechnology - May 18, 2015
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates, Nature Materials