Publications
Medical Congresses
- February 2022
SIG-005
Development of a Novel Encapsulated Non-Viral Cell-Based, BBB-Penetrant Therapy for MPS I, WORLDSymposium 2022 - February 2022
SIG-020
Development of a Novel Encapsulated Non-Viral Cell-Based Therapy for MPS VI, WORLDSymposium 2022 - February 2022
SIG-005
Development of a Novel Encapsulated Non-Viral Cell-Based, BBB-Penetrant Therapy for MPS I, WORLDSymposium 2022 - July 2021
SIG-005
SIG 005: Novel Encapsulated Non Viral Cell Based Therapy for MPS 1, MPS 2021 - July 2021
SIG-020
Development of a novel encapsulated non-viral cell-based therapy for MPS-6, MPS 2021 - July 2021
SIG-018
SIG-018: novel encapsulated non-viral cell-based therapy for MPS-2, MPS 2021 - May 2021
Autoimmune Hepatitis
Continuous IL 10 Therapy Prevents Liver Damage in Preclinical Model of Autoimmune Hepatitis, ASGCT 2021 - May 2021
Hypoparathyroidism
Tunable Delivery of Parathyroid Hormone with the Shielded Living Therapeutics TM Platform Provides a New Modality for Treatment of Hypoparathyroidism, ASGCT 2021 - May 2021
SLTx Platform
Analytical Development Considerations for the Shielded Living Therapeutics Platform: A Novel Encapsulated Cell-Based, Non-Viral Platform for Delivery of Therapeutic Proteins, ASGCT 2021 - May 2021
SLTx Platform
A Scaled and Semi-Automated Cell Encapsulation Process for a Shielded Cell-Based Platform for Chronic Diseases, ASGCT 2021 - February 2021
SIG-018
SIG-018: Novel Encapsulated Non-Viral Cell-Based Therapy for MPS II, WORLDSymposium 2021 - February 2021
SIG-020
Development of a Novel Encapsulated Non Viral Cell Based Therapy for MPS VI, WORLDSymposium 2021 - February 2021
SIG-007
SIG-007: Novel Encapsulated Non-Viral Cell-Based Therapy for Fabry, WORLDSymposium 2021 - February 2021
SIG-005
SIG-005: Novel Encapsulated Non-Viral Cell-Based Therapy for MPS I, WORLDSymposium 2021 - December 2020
SIG-001
First-in-Human Phase 1/2 Clinical Trial of SIG-001, an Innovative Shielded Cell Therapy Platform, for Hemophilia A, ASH 2020, Abstract - July 2020
SIG-001
SIG-001 for Hemophilia A: Preclinical Safety and Efficacy Studies Conducted in Mice and Non-Human Primates, ISTH 2020, Abstract - May 2020
SLTx Platform
Optimization of Shielded Encapsulated Cell Therapy for Hemophilia and Beyond, ASGCT 2020, Abstract - February 2020
SIG-009
Correcting FVII Deficiency Using Coagulation Factors Produced in Vivo by Encapsulated Engineered Allogeneic Cells, EAHAD 2020, Abstract - February 2020
SIG-005
Preclinical Development of SIG-005 for Treatment of MPS1, WORLD Symposium 2020, Abstract - February 2020
SIG-007
Preclinical Development of SIG-007 for Treatment of Fabry Disease, WORLD Symposium 2020, Abstract - December 2019
SIG-001
Correcting Rare Blood Disorders Using Coagulation Factors Produced in vivo by Shielded Living Therapeutics™ Products, ASH 2019, Abstract
Peer Reviewed Publications
- March 30, 2020
A Retrievable Implant for the Long-Term Encapsulation and Survival of Therapeutic Xenogeneic Cells, Nature Biomedical Engineering - Winter 2019-2020
Hemophilia Federation of America's 2019-20 Special Dateline Federation Magazine: Emerging Therapies, Hemophilia Federation of America - August 13, 2018
Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques, Nature Biomedical Engineering - July 30, 2018
Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer, Nature Biomedical Engineering - April 12, 2018
Evolving Industry Partnerships and Investments in Cell and Gene Therapies, Cell Stem Cell - April 2, 2018
Future Therapies Using Implanted Engineered Cells as Protein Factories, PharmTech - December 11, 2018
Coated glucose sensors dodge recalibration, Nature Biomedical Engineering - March 20, 2017
Colony stimulating factor-1 receptor is a central component ofthe foreign body response tobiomaterial implants in rodents and non-human primates, Nature Materials - January 25, 2016
Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice, Nature Medicine - January 25, 2016
Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates, Nature Biotechnology - May 18, 2015
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates, Nature Materials