Publications

Medical Congresses

• February 2022
  SIG-005
  Development of a Novel Encapsulated Non-Viral Cell-Based, BBB-Penetrant Therapy for MPS I, WORLDSymposium 2022
• February 2022
  SIG-020
  Development of a Novel Encapsulated Non-Viral Cell-Based Therapy for MPS VI, WORLDSymposium 2022
• February 2022
  SIG-005
  Development of a Novel Encapsulated Non-Viral Cell-Based, BBB-Penetrant Therapy for MPS I, WORLDSymposium 2022
• July 2021
  SIG-005
  SIG 005: Novel Encapsulated Non Viral Cell Based Therapy for MPS 1, MPS 2021
• July 2021
  SIG-020
  Development of a novel encapsulated non-viral cell-based therapy for MPS-6, MPS 2021
• July 2021
  SIG-018
  SIG-018: novel encapsulated non-viral cell-based therapy for MPS-2, MPS 2021
• May 2021
  Autoimmune Hepatitis
  Continuous IL 10 Therapy Prevents Liver Damage in Preclinical Model of Autoimmune Hepatitis, ASGCT 2021
• May 2021
  Hypoparathyroidism
  Tunable Delivery of Parathyroid Hormone with the Shielded Living Therapeutics TM Platform Provides a New Modality for Treatment of Hypoparathyroidism, ASGCT 2021
• May 2021
  SLTx Platform
  Analytical Development Considerations for the Shielded Living Therapeutics Platform: A Novel Encapsulated Cell-Based, Non-Viral Platform for Delivery of Therapeutic Proteins, ASGCT 2021
• May 2021
  SLTx Platform
  A Scaled and Semi-Automated Cell Encapsulation Process for a Shielded Cell-Based Platform for Chronic Diseases, ASGCT 2021
• February 2021
  SIG-018
  SIG-018: Novel Encapsulated Non-Viral Cell-Based Therapy for MPS II, WORLDSymposium 2021
• February 2021
  SIG-020
  Development of a Novel Encapsulated Non Viral Cell Based Therapy for MPS VI, WORLDSymposium 2021
• February 2021
  SIG-007
  SIG-007: Novel Encapsulated Non-Viral Cell-Based Therapy for Fabry, WORLDSymposium 2021
• February 2021
  SIG-005
  SIG-005: Novel Encapsulated Non-Viral Cell-Based Therapy for MPS I, WORLDSymposium 2021
• December 2020
  SIG-001
  First-in-Human Phase 1/2 Clinical Trial of SIG-001, an Innovative Shielded Cell Therapy Platform, for Hemophilia A, ASH 2020, Abstract
• July 2020
  SIG-001
  SIG-001 for Hemophilia A: Preclinical Safety and Efficacy Studies Conducted in Mice and Non-Human Primates, ISTH 2020, Abstract
• May 2020
  SLTx Platform
  Optimization of Shielded Encapsulated Cell Therapy for Hemophilia and Beyond, ASGCT 2020, Abstract
• February 2020
  SIG-009
  Correcting FVII Deficiency Using Coagulation Factors Produced in Vivo by Encapsulated Engineered Allogeneic Cells, EAHAD 2020, Abstract
• February 2020
  SIG-005
  Preclinical Development of SIG-005 for Treatment of MPS1, WORLD Symposium 2020, Abstract
• February 2020
  SIG-007
  Preclinical Development of SIG-007 for Treatment of Fabry Disease, WORLD Symposium 2020, Abstract
• December 2019
  SIG-001
  Correcting Rare Blood Disorders Using Coagulation Factors Produced in vivo by Shielded Living Therapeutics^™ Products, ASH 2019, Abstract

Peer Reviewed Publications

• March 30, 2020
  A Retrievable Implant for the Long-Term Encapsulation and Survival of Therapeutic Xenogeneic Cells, Nature Biomedical Engineering
• Winter 2019-2020
  Hemophilia Federation of America's 2019-20 Special Dateline Federation Magazine: Emerging Therapies, Hemophilia Federation of America
• August 13, 2018
  Alginate encapsulation as long-term immune protection of allogeneic pancreatic islet cells transplanted into the omental bursa of macaques, Nature Biomedical Engineering
• July 30, 2018
  Reduction of measurement noise in a continuous glucose monitor by coating the sensor with a zwitterionic polymer, Nature Biomedical Engineering
• April 12, 2018
  Evolving Industry Partnerships and Investments in Cell and Gene Therapies, Cell Stem Cell
• April 2, 2018
  Future Therapies Using Implanted Engineered Cells as Protein Factories, PharmTech
• December 11, 2018
  Coated glucose sensors dodge recalibration, Nature Biomedical Engineering
• March 20, 2017
  Colony stimulating factor-1 receptor is a central component ofthe foreign body response tobiomaterial implants in rodents and non-human primates, Nature Materials
• January 25, 2016
  Long-term glycemic control using polymer-encapsulated human stem cell–derived beta cells in immune-competent mice, Nature Medicine
• January 25, 2016
  Combinatorial hydrogel library enables identification of materials that mitigate the foreign body response in primates, Nature Biotechnology
• May 18, 2015
  Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates, Nature Materials