Addressing a broad range of chronic diseases
Our Shielded Living TherapeuticsTM platform combines advanced cell engineering with innovations in biocompatible materials, potentially enabling our products to produce a wide range of therapeutic molecules that may be missing or deficient in the body, including proteins, antibodies and enzymes.
Our pipeline currently spans three disease areas – including rare blood, lysosomal, and endocrine diseases – with product candidates designed to be off-the-shelf, durable, controllable and redosable, without requiring modification of the patient’s genes or immunosuppression.
Based on earlier preclinical data, we believe that SIG-001, our lead product candidate, has the potential to prevent bleeding episodes in patients with moderate-severe to severe hemophilia A by continuously secreting human FVIII. We are currently enrolling patients in a Phase 1/2 trial in this indication, as we continue to advance our other programs toward the clinic.
Program | Discovery | Lead Optimization | IND Enabling | Phase 1/2 | Phase 3 | |||||
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Rare Blood Disorders | ||||||||||
SIG-001 - Hemophilia A* |
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SIG-009 - FVII Deficiency |
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SIG-003 - Hemophilia B |
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Lysosomal Diseases | ||||||||||
SIG-005 - MPS-1 |
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SIG-007 - Fabry |
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SIG-018 - MPS-2 |
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Endocrine & Other Chronic Diseases | ||||||||||
SIG-002 - Type 1 Diabetes** |
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SIG-014 - Wet AMD |
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SIG-015 - Immune-Mediated Diseases |
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*IND and CTA cleared.
**Sigilon is leading execution of the program through IND and Eli Lilly and Company (Lilly), a global leader in diabetes, will develop and commercialize the program worldwide.