Current Openings

  • Company Overview

    Sigilon Therapeutics seeks to develop functional cures for chronic diseases through its Shielded Living Therapeutics™ platform. Sigilon’s product candidates are non-viral engineered cell-based therapies designed to produce the crucial proteins, enzymes or factors needed by patients living with chronic diseases such as hemophilia, lysosomal diseases, and diabetes. The engineered cells are protected by Sigilon’s Afibromer™ biomaterials matrix, which shields them from immune rejection and fibrosis. Sigilon was founded by Flagship Pioneering in conjunction with Daniel Anderson, Ph.D., and Robert Langer, Sc.D., of the Massachusetts Institute of Technology.

    Sigilon Therapeutics is searching for an energized and highly motivated candidate Senior/Principal Associate Scientist to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading-edge pancreatic islet cell technology. The individual in this position will be a key member of the highly collaborative Diabetes Research team working to optimize and characterize a novel cell therapy technology. A successful candidate will have demonstrated experience in mammalian cell and tissue culture processes as well as expertise with cell and molecular biology assays. This will be an exciting role with the opportunity to be highly impactful for advancing the diabetes program at Sigilon.

    Responsibilities

    • Execute and analyze cell-based and molecular biology assays,including flow cytometry, qPCR,cell viability, and immunohistochemistry
    • Cell/tissue culture ofmammalian and pluripotent stem cell lines in 2- and 3-dimensional culture vessels
    • Demonstrate understanding and application of relevant scientific literature to the design of experimental protocols and data interpretation
    • Present data and interpretation of results in multidisciplinary team meetings
    • Coordinate with a collaborative team of scientists and engineers to ensure the completion of the team’s research objectives
    • Establish laboratory protocols and SOPs
    • Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook
    • Comply with standard laboratory practices and company policies

    Requirements

    • BS or MS degree with a focus on biology, molecular biology, cell biology, or related field
    • Three to six yearshands-on laboratory experience, with some industry experience preferred
    • Experience in tissue culture and cell-based and molecular biology assays; expertise in flow cytometry techniques and analyses highly desirable
    • Outstanding interpersonal skills and established collaborative working habits
    • Excellent oral and written communication skills
    • Must enjoy coming to work and having fun while creating therapies that improve the lives of patients