Courage to create something that matters

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We are ONE.
We, TOGETHER, are Sigilon.

We care deeply about patients’ and caregivers’ struggles, stories, and triumphs.

We care about rigorous science addressing critical patient needs

Learn how we care

We strive to earn and keep the trust of patients, caregivers, and partners.

We respect each other, embrace diversity, and work as one team.

Learn how we trust

We are passionate about the impact of groundbreaking discoveries.

We dream big and don’t fear failure. We ask “What if we could…?”

Learn how we pioneer

We build value for patients and their families, clinicians, partners, and shareholders.

We make sure every experiment and decision counts.

Learn how we create

We visualize success and make it happen.

We operate with urgency; patients can’t wait.

Learn how we act

Always Growing

We are change-makers, and we never stop in our quest to advance therapies for patients in need. For us that takes a number of forms — we stay abreast of the most recent Sigilon science at our Sigilon Monthly Sessions, where a team member presents their findings and cross-pollination of ideas is encouraged; we also meet up informally, around the weekly Friday breakfast or in our collaboration hubs outside the lab. In this way, we’re always inspiring one another and advancing science that matters.

Never Losing Sight of Our Purpose

We’re at Sigilon to make a difference for patients, and that is front and center in our day to day work. We host patients and caregivers at our offices to learn more about the disease areas we aim to treat. And we stay engaged with the broader community, from organizing a fundraiser to send young people to the New England Hemophilia Association Family Camp, to sponsoring rare disease awareness efforts.

Enjoying Our Relationships

From our Sigilon running team to occasional yoga outings to escape rooms and offsite retreats, we really enjoy our teamwork in all forms. We are a close-knit team with an upbeat atmosphere, and it shows in our productive science — a true team effort.

Life at Sigilon

My favorite part of the culture at Sigilon is that there’s a balance, which I think is very important in a work environment. There’s a balance between making sure that the employee’s needs are met, but the science is still also a focus and priority.

Rupinderjit

Associate Scientist, Islet Cell Therapy

‘We Together’ is our motto, and there is a reason we selected that. We feel we cannot do anything alone; our science and our functions are so unique that there is no one person that knows everything, but if we put our minds and our hearts and our hands together, we can achieve a lot.

Vanya

Vice President, Head of Human Resources

I think teamwork is very important in the lab because we all are just resources. We can’t know everything, we can’t do everything, so the fact that everyone is there to help you, to contribute to your success, is very important here.

Shaleen

Senior Associate Scientist, Molecular Biology

Everybody’s just nice, smart and interesting to talk to. They’re all about the passion and trying to reach the end goal of helping people, and all of those aspects combined together make Sigilon a great place to work.

Olivia

Vice President, Head of Islet Cell Therapy Research

I think one of the things that’s exciting at Sigilon is that there’s a lot of different components of what we’re trying to do here. There’s always a lot of new learnings and developments that are coming out of the various teams that make up Sigilon.

Ryan

Senior Project Manager, Portfolio

We’ve created an environment here where people are collaborative and friendly, and it makes it enjoyable coming to work every day.

Justin

Senior Project Manager

Current openings

Sigilon Therapeutics is looking for an experienced process development scientist to join the team responsible for enhancing and evolving the manufacturing process for Sigilon’s encapsulated allogeneic cell therapy platform. Key objectives will be to develop robust and scalable cell therapy bioprocesses and transfer these processes to contract manufacturing partners.
KEY RESPONSIBILITIES
- Design and execute process development laboratory studies that support the evaluation, development and implementation of new technologies for cell therapy manufacturing.
- Perform hands-on lab-based activities in a cell culture lab, including analysis and communication of results to cross-functional teams.
- Perform process or equipment analysis and trend process or equipment performance.
- Provide process training to GMP personnel.
- Support technology transfer and GMP manufacturing operations as needed.
- Perform statistical analysis including design of experiments (DOEs) as appropriate.
- Write and review technical documentation, technical SOPs, draft manufacturing batch records, technical reports and summary reports.
- Support qualification and risk assessment activities for GMP implementation.
PROFESSIONAL EXPERIENCE/QUALIFICATIONS
- BS in Biochemical Engineering, Chemical Engineering, Biomedical Engineering, Biotechnology or related discipline with 3+ years biologics manufacturing & process development experience required. Cell therapy specific experience preferred
- Strong analytical skills to perform statistical analysis as well as proficiency in statistical software (R, JMP, Minitab)
- Established cell culture lab techniques and aseptic processing in a BSC such as cell passaging, sampling, fluid handling, media formulation, managing reagents, and cryopreservation.
- Mastery of scientific and engineering principles related to upstream bioprocessing including scale-up / scale-out approaches, hydrodynamics, mass transfer, and bioreactor design and monitoring is desired
- Practical knowledge of cGMP manufacturing and regulatory regulations and requirements for pharmaceuticals and devices.
Apply Now
Sigilon Therapeutics is searching for an energized and highly motivated Sr. Associate Scientist to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. The candidate should have experience with tissue culture of cell lines and with cell and molecular biology assays.
Responsibilities
Tissue culture of cell lines and pluripotent stem cell lines
Reagent preparation, lab organization and daily maintenance of long-term experiments
Perform cell-based and molecular biology assays, including cell viability, flow cytometry, qPCR, and functional assays
Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook
Present results of experiments and findings in multidisciplinary team meetings
Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects
Comply with standard laboratory practices and company policies
Requirements
Sc. with 3+ years industry experience or M.Sc. degree with 2+ years industry experience with a focus on biology, molecular biology or cell biology
At least 2 years laboratory experience in industry or academia desirable
Experience in tissue culture and cell-based and molecular biology assays, e.g. qPCR, immunohistochemistry, ELISA, and flow cytometry a plus
Organization, attention to detail, willingness to learn new techniques and scientific curiosity a must
Outstanding interpersonal skills and established collaborative working habits
Excellent oral and written communication skills
Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
Apply Now
Sigilon Therapeutics, Inc. is looking to add an Accounts Payable/Accountant to our growing staff. The role will interact closely with all levels of management and staff, as well as outside service providers (vendors, consultants, attorneys, etc.).
The person will report directly to the Assistant Controller and will be responsible for general accounting and accounts payable responsibilities among other tasks.
Responsibilities:
All day-to-day accounts payable invoice operations, including vendor management, invoice entry and 3-way PO matching in the Procure-To-Pay system (Prendio)
Review and administration of purchase orders working directly with members of the business to ensure completeness and accuracy of financial information, including proper coding and approvals
Oversee the Company’s corporate credit cards and related monthly reconciliation
Prepare Concur system and related expense reports processes and journals
Manage the complete prepaid, fixed assets and accruals processes, including timely entries in NetSuite and reconciliations
Work on 1099 filing preparation
Assist with the monthly closing and financial reporting processes as needed
Assist in the preparation of materials to support audit requirements/requests including interacting with auditors
Assist with updates to formal internal control documentation in compliance with Sarbanes-Oxley (“SOX”) and ensure responsibilities perform under appropriate internal control requirements
Oversee the work of a part-time AP Clerk
Assist with R&D Budget versus Actuals analysis
Other ad hoc projects or accounting and finance duties as needed
Requirements:
Accounts payable / procure-to-pay / accounting experience required (3+ years) - Biotech/Lifesciences experience is a plus
Experience with procure-to-pay (Prendio a plus) and accounting software (NetSuite a plus)
Strong working knowledge of Excel and MS Office
Detail oriented and well organized
Able to communicate with others with professionalism attitude
Ability to meet deadlines and prioritize tasks
Ability to multi-task and work in a fast paced, start-up environment
Self-motivated and eager to take advantage of an opportunity at a fast-growing company
Apply Now
The employee will lead cross functional teams to drive development programs from research through commercial launch to meet the company’s goals and effectively treat patients. The successful candidate will have a strong knowledge of product development, regulatory requirements, preclinical studies, and manufacturing preferably for cell-based therapy. An ability to think outside of the box and experience with combination products will benefit the candidate for this role. The candidate will also have an excellent execution track record on for on-time delivery, as well as demonstrable strategic insight, creativity for overcoming challenges, and program prioritization skills. This role will require daily interaction with stakeholders in program management, engineering, biology, non-clinical, quality, regulatory, manufacturing, and clinical teams as well as external teams. Presentation of written and oral summaries of progress to senior management and expert consultants will be required.

Responsibilities:

· Lead cross functional team to drive development programs exiting research through to commercial launch

· Lead multi-disciplinary project teams through demonstrating an in-depth knowledge of biologic/combination product development, excellent interpersonal communication skills, leadership skills, and influencing skills

· Ensure transparency throughout development by securing project resources and communicate gaps, identify risks and mitigate/communicate to management, and define critical path items and alert team to changes to critical path items

· Proactively anticipate issues, challenges, and assumptions as well as identify contingencies or creative opportunities to circumvent potential delays

· Guide the team in appropriate decision-making through analyzing options and reviewing implications

· Develop and maintain timelines in partnership with program management for development programs

· Partner with technical leads/SMEs to establish requirements for program success

· Coordinate with nonclinical team for execution of all studies required for regulatory filings

· Work with engineering and encapsulation team to push readiness of product enabling technologies such as packaging, stability, delivery and surgical technique development

· Synchronize with clinical team to ensure readiness of program for trial initiation

· Maintain documentation and write reports to support quality requirements, regulatory filings, IP as needed

Requirements/experience with:

· At least 10+ years of relevant industry experience in product development and program management

· MS or PhD preferred; biomedical engineering, biology, program management, or similar field

· Strategic thinker, able to assess the program needs and prioritize according to corporate timelines

· People leadership and mentorship capabilities

· Experience with reparation of FDA submission documents, FDA interactions

· Experience in design, optimization, testing, data analysis and validation protocols

· Outstanding interpersonal skills and established collaborative working habits

· Excellent oral and written communication skills

· Must be available to start work in the immediate future; authorization to work in the US

Apply Now
Responsibilities:

Perform preclinical in vivo studies in rodents, which requires surgery, necropsy, test article administration and blood and tissue collection for analysis

Understand and ensure compliance with IACUC protocols and EHS regulations

In a matrix environment, collaborate with team members and coordinate assigned activities
with other teams to ensure timely completion

Make observations, evaluate data, interpret results and document in a
well-maintained laboratory notebook and study reports in timely fashion

Comply with standard laboratory practices and company policies

Work with team leads to evaluate histopathology assays and perform imaging for internal
programs

Participate in discussions to optimize protocols, tools, or methods for project advancement

Apply relevant scientific literature to the design of experimental protocols

Present study results of experiments and findings in multidisciplinary team meetings

Requirements:

B.Sc. degree in biology or similar degree

2+ years industry experience working in a vivarium is desirable

Proficiency in rodent handling, blood collection, tissue harvesting and processing of
biological samples for ex vivo analysis is required

Experience in rodent surgery, especially laparotomy is highly desirable

Experience in histopathological techniques such as tissue sectioning, staining, and microscopy imaging is a plus

Outstanding sense of urgency, interpersonal skills and established collaborative working habits in a dynamic,
matrixed environment

Excellent oral and written communication skills and time management

Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
Apply Now
Responsibilities:
Tissue culture of primary cells and cell linesStable transfection and selection of engineered cell linesPerform functional and viability cell-based assaysMolecular and cell biology techniques, including ELISA, western blot, and PCR
Work in a matrixed environment to insure engineered cell lines meet the needs of the in vivo and cell biology teams
With increasing independence, plan, design and execute of a series of experiments that provide the research findings necessary for the completion of an assigned project
Demonstrate understanding and application of relevant scientific literature to the design of experimental protocols
Participate in discussions on optimizing protocols, tools, programs and/or new methods for project advancement and make the approved changes
Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook
Present results of experiments and findings in multidisciplinary team meetings
Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects
Comply with standard laboratory practices and company policies
Requirements:
B.Sc. or M.Sc. degree with a focus on molecular and cellular biology
1+ years industry experience desirable
Experience in tissue culture, cell-based assays, qPCR, western-blotting, ELISA, and flow cytometry
Outstanding interpersonal skills and established collaborative working habits.
Excellent oral and written communication skills
Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
Apply Now
Responsibilities:
Lead the efforts identifying, researching and developing pipeline indications for Sigilon platform technology
Accountable for design, implementation, and interpretation of key go/no-go preclinical experiments directed to advancing new disease areas and indications – both in vitro and in vivo disease models
Own the relationships with internal and external KOLs
Investigate and condense complex disease areas for presentation to leadership
Responsible for keeping up with literature and cutting-edge techniques
Requirements:
Ph.D. degree required in a biological field of study
Experience in rare blood disorders is preferred
Strong and diverse understanding of disease pathophysiology
Experience with cell therapies and in vivo disease models a plus
Outstanding interpersonal skills and established collaborative working habits
Excellent oral and written communication skills
Apply Now
Sigilonis seeking a highly motivated, creative, and driven Director/ Sr. Director Business Developmentto join our team. The Director/ Sr. Director, Business Development will drive ongoing and initiate new business & corporate development activities, support in-licensing & out-licensing activities, establish new & manage existing academic partnerships.This is an opportunity to contribute considerably to a top-tier, fast-paced, rapidly growing, private biotechnology company. This position will report to the Chief Business Officer.
Responsibilities:
Contribute to all aspects of business development and strategy
Identify and reach to potential partners to evaluate new strategic partnership opportunities to further expand the application of our platform technology
Represent Sigilon in discussions and works collaboratively with current and potential partners
Continually monitor the business development landscape and maintain a database of deal making analytical
Coordinate and participate in due diligence processes, including organizing and maintaining the data rooms
Track and document the status of business development discussions
Support the evaluation of potential business opportunities by developing commercial assessments, product and indication planning and leading analytical and quantitative analyses (e.g. valuation, build market model assessment, transaction financial structuring & comparable analyses)
Develop and negotiate term sheets and identify solutions when needed to reach agreement on
key deal terms
Represent Sigilon at partnering events and conferences to increase awareness of our company and
our strategy for partnering
Work cross-functionally with all functions, including research, development, manufacturing,
finance, and legal/IP to support and drive our business development strategy and functions
Partner with R&D leadership to align on strategy for platform enhancement. Identify technologies with academic and biotechnology/pharmaceutical partners to in license to support our research strategy
Manage academic and biotech alliances
Other duties may be considered such as driving competitive intelligence and supporting valuation
models for internal pipeline programs
Qualifications & Education:
Bachelor's degree (preferably in a scientific discipline) plus advanced degree (M.S., Ph.D., M.D., and/or M.B.A.)
Minimum 7 years of business development experience within biotechnology, life
sciences consulting, or pharmaceutical industry
Strategic creative thinker with ability to establish innovative business solutions,
structures and concepts
Strong business and financial acumen with superior quantitative analytical and modelling skills
Demonstrated ability to successfully support deal execution from sourcing to deal close
Proactive, team player with strong sense of urgency and excellent collaborative skills
Strong oral, written communication, and presentations skills
Excellent planning, organizational, and time management skills with attention to details
Ability to thrive in a fast-paced, dynamic, and innovative environment
Leadership in managing due diligence
Excellent skills with Microsoft Office Applications; Word, Excel, Outlook and industry databases (such as drug pipelines and deal databases)
Apply Now