Courage to create something that matters
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We are ONE.
We, TOGETHER, are Sigilon.
We care deeply about patients’ and caregivers’ struggles, stories, and triumphs.
We care about rigorous science addressing critical patient needs
We strive to earn and keep the trust of patients, caregivers, and partners.
We respect each other, embrace diversity, and work as one team.
We are passionate about the impact of groundbreaking discoveries.
We dream big and don’t fear failure. We ask “What if we could…?”
We build value for patients and their families, clinicians, partners, and shareholders.
We make sure every experiment and decision counts.
We visualize success and make it happen.
We operate with urgency; patients can’t wait.
Always Growing
We are change-makers, and we never stop in our quest to advance therapies for patients in need. For us that takes a number of forms — we stay abreast of the most recent Sigilon science at our Sigilon Monthly Sessions, where a team member presents their findings and cross-pollination of ideas is encouraged; we also meet up informally, around the weekly Friday breakfast or in our collaboration hubs outside the lab. In this way, we’re always inspiring one another and advancing science that matters.
Never Losing Sight of Our Purpose
We’re at Sigilon to make a difference for patients, and that is front and center in our day to day work. We host patients and caregivers at our offices to learn more about the disease areas we aim to treat. And we stay engaged with the broader community, from organizing a fundraiser to send young people to the New England Hemophilia Association Family Camp, to sponsoring rare disease awareness efforts.
Life at Sigilon
I love that we have a fast-paced scientific workplace but where people are so approachable and friendly.
Guillaume
Associate Director, Therapeutic Lead, Hemophilia
My favorite part of the culture at Sigilon is that there’s a balance, which I think is very important in a work environment. There’s a balance between making sure that the employee’s needs are met, but the science is still also a focus and priority.
Rupinderjit
Associate Scientist, Islet Cell Therapy
‘We Together’ is our motto, and there is a reason we selected that. We feel we cannot do anything alone; our science and our functions are so unique that there is no one person that knows everything, but if we put our minds and our hearts and our hands together, we can achieve a lot.
Vanya
Vice President, Head of Human Resources
I think teamwork is very important in the lab because we all are just resources. We can’t know everything, we can’t do everything, so the fact that everyone is there to help you, to contribute to your success, is very important here.
Shaleen
Senior Associate Scientist, Molecular Biology
Everybody’s just nice, smart and interesting to talk to. They’re all about the passion and trying to reach the end goal of helping people, and all of those aspects combined together make Sigilon a great place to work.
Olivia
Vice President, Head of Islet Cell Therapy Research
I think one of the things that’s exciting at Sigilon is that there’s a lot of different components of what we’re trying to do here. There’s always a lot of new learnings and developments that are coming out of the various teams that make up Sigilon.
Ryan
Senior Project Manager, Portfolio
We’ve created an environment here where people are collaborative and friendly, and it makes it enjoyable coming to work every day.
Justin
Senior Project Manager
Current openings
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Sigilon Therapeutics is searching for an energized and highly motivated Sr. Associate Scientist to be part of a team focused on developing a novel therapeutic product for Rare Disease utilizing Sigilon’s Afibromer™ technology. The candidate should have experience in rare disease, including cell culture experience, functional cellular analyses, sample preparation for analyses of samples from in vivo/ in vitro work.
Responsibilities
- Tissue culture of primary cells and recombinant cell lines
- Perform and interpret data from cell-based assays and molecular biology assays
- Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook
- Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects
- Comply with standard laboratory practices and company policies
Requirements
- BS or MS degree in the biological sciences , MS preferred
- 2+ years experience in industry or academia investigating with rare diseases field. Includingsample preparation and analysis from in vitro and in vivo is a plus
- Outstanding interpersonal skills and established collaborative working habits
- Skills in MS Office: Word, PowerPoint, Excel, Outlook
- Ability to work and succeed within a matrixed organization
- Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
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Sigilonis seeking a highly motivated, creative, and driven Director/ Sr. Director Business Developmentto join our team. The Director/ Sr. Director, Business Development will drive ongoing and initiate new business & corporate development activities, support in-licensing & out-licensing activities, establish new & manage existing academic partnerships.This is an opportunity to contribute considerably to a top-tier, fast-paced, rapidly growing, private biotechnology company. This position will report to the Chief Business Officer.
Responsibilities:
- Contribute to all aspects of business development and strategy
- Identify and reach to potential partners to evaluate new strategic partnership opportunities to further expand the application of our platform technology
- Represent Sigilon in discussions and works collaboratively with current and potential partners
- Continually monitor the business development landscape and maintain a database of deal making analytical
- Coordinate and participate in due diligence processes, including organizing and maintaining the data rooms
- Track and document the status of business development discussions
- Support the evaluation of potential business opportunities by developing commercial assessments, product and indication planning and leading analytical and quantitative analyses (e.g. valuation, build market model assessment, transaction financial structuring & comparable analyses)
- Develop and negotiate term sheets and identify solutions when needed to reach agreement on
key deal terms - Represent Sigilon at partnering events and conferences to increase awareness of our company and
our strategy for partnering - Work cross-functionally with all functions, including research, development, manufacturing,
finance, and legal/IP to support and drive our business development strategy and functions - Partner with R&D leadership to align on strategy for platform enhancement. Identify technologies with academic and biotechnology/pharmaceutical partners to in license to support our research strategy
- Manage academic and biotech alliances
- Other duties may be considered such as driving competitive intelligence and supporting valuation
models for internal pipeline programs
Qualifications & Education:
- Bachelor's degree (preferably in a scientific discipline) plus advanced degree (M.S., Ph.D., M.D., and/or M.B.A.)
- Minimum 7 years of business development experience within biotechnology, life
sciences consulting, or pharmaceutical industry - Strategic creative thinker with ability to establish innovative business solutions,
structures and concepts - Strong business and financial acumen with superior quantitative analytical and modelling skills
- Demonstrated ability to successfully support deal execution from sourcing to deal close
- Proactive, team player with strong sense of urgency and excellent collaborative skills
- Strong oral, written communication, and presentations skills
- Excellent planning, organizational, and time management skills with attention to details
- Ability to thrive in a fast-paced, dynamic, and innovative environment
- Leadership in managing due diligence
- Excellent skills with Microsoft Office Applications; Word, Excel, Outlook and industry databases (such as drug pipelines and deal databases)
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- Perform preclinical in vivo studies in rodents, which requires surgery, necropsy, test article administration and blood and tissue collection for analysis
- Understand and ensure compliance with IACUC protocols and EHS regulations
with other teams to ensure timely completion
well-maintained laboratory notebook and study reports in timely fashion
programs
biological samples for ex vivo analysis is required- Experience in histopathological techniques such as tissue sectioning, staining, and microscopy imaging is a plus
- Outstanding sense of urgency, interpersonal skills and established collaborative working habits in a dynamic,
matrixed environment - Excellent oral and written communication skills and time management
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The employee will lead cross functional teams to drive development programs from research through commercial launch to meet the company’s goals and effectively treat patients. The successful candidate will have a strong knowledge of product development, regulatory requirements, preclinical studies, and manufacturing preferably for cell-based therapy. An ability to think outside of the box and experience with combination products will benefit the candidate for this role. The candidate will also have an excellent execution track record on for on-time delivery, as well as demonstrable strategic insight, creativity for overcoming challenges, and program prioritization skills. This role will require daily interaction with stakeholders in program management, engineering, biology, non-clinical, quality, regulatory, manufacturing, and clinical teams as well as external teams. Presentation of written and oral summaries of progress to senior management and expert consultants will be required.
Responsibilities:
· Lead cross functional team to drive development programs exiting research through to commercial launch
· Lead multi-disciplinary project teams through demonstrating an in-depth knowledge of biologic/combination product development, excellent interpersonal communication skills, leadership skills, and influencing skills
· Ensure transparency throughout development by securing project resources and communicate gaps, identify risks and mitigate/communicate to management, and define critical path items and alert team to changes to critical path items
· Proactively anticipate issues, challenges, and assumptions as well as identify contingencies or creative opportunities to circumvent potential delays
· Guide the team in appropriate decision-making through analyzing options and reviewing implications
· Develop and maintain timelines in partnership with program management for development programs
· Partner with technical leads/SMEs to establish requirements for program success
· Coordinate with nonclinical team for execution of all studies required for regulatory filings
· Work with engineering and encapsulation team to push readiness of product enabling technologies such as packaging, stability, delivery and surgical technique development
· Synchronize with clinical team to ensure readiness of program for trial initiation
· Maintain documentation and write reports to support quality requirements, regulatory filings, IP as needed
Requirements/experience with:
· At least 10+ years of relevant industry experience in product development and program management
· MS or PhD preferred; biomedical engineering, biology, program management, or similar field
· Strategic thinker, able to assess the program needs and prioritize according to corporate timelines
· People leadership and mentorship capabilities
· Experience with reparation of FDA submission documents, FDA interactions
· Experience in design, optimization, testing, data analysis and validation protocols
· Outstanding interpersonal skills and established collaborative working habits
· Excellent oral and written communication skills
· Must be available to start work in the immediate future; authorization to work in the US
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Sigilon Therapeutics is searching for an energized and highly motivated Sr. Associate Scientist to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. The candidate should have experience with tissue culture of cell lines and with cell and molecular biology assays.
Responsibilities
- Tissue culture of cell lines and pluripotent stem cell lines
- Reagent preparation, lab organization and daily maintenance of long-term experiments
- Perform cell-based and molecular biology assays, including cell viability, flow cytometry, qPCR, and functional assays
- Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook
- Present results of experiments and findings in multidisciplinary team meetings
- Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects
- Comply with standard laboratory practices and company policies
Requirements
- Sc. or M.Sc. degree with a focus on biology, molecular biology or cell biology
- 2 years laboratory experience in industry or academia desirable
- Experience in tissue culture and cell-based and molecular biology assays, e.g. qPCR, immunohistochemistry, ELISA, and flow cytometry a plus
- Organization, attention to detail, willingness to learn new techniques and scientific curiosity a must
- Outstanding interpersonal skills and established collaborative working habits
- Excellent oral and written communication skills
- Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
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Sigilon Therapeutics is searching for an energized and highly motivated Principal Associate/Assistant Scientist
to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. The candidate should have MS level experience in molecular or stem cell biology, experience in physiology/diabetes a plus.Responsibilities
- Tissue culture of stem cell (iPSC) lines
- Preparation of reagents for long-term differentiation experiments
- Bioreactor-based pancreatic differentiation of iPS cells
- Design, perform, and interpret data from cell-based assays and molecular biology assays
- Troubleshoot experiments, establish protocols and SOPs
- Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook
- Present results of experiments and findings in multidisciplinary team meetings
- Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the
team’s research projects - Comply with standard laboratory practices and company policies
Requirements
- MS degree in molecular or cellular biology or a similar field
- Experience in tissue culture, flow cytometry, IFC, gene expression analysis
- Previous industry experience in early drug discovery a plus
- Outstanding interpersonal skills and established collaborative working habits
- Excellent oral and written communication skills
- Skills in MS Office: Word, PowerPoint, Excel, Outlook
- Ability to work and succeed within a matrixed organization
- Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
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Sigilon Therapeutics is seeking an individual with expertise in gene/cell therapy clinical supply, excellent communication skills, and the ability to work in a highly interactive and matrixed environment. The incumbent will oversee day to day patient supply activities for Sigilon clinical trials; including planning and distribution of final products to clinical sites. This role will require daily interaction with stakeholders including but not limited to Clinical Operations, Clinical Research Organizations, Quality, and External Manufacturing. Presentation of
written and oral summaries of progress in team meetings as well as to management is expected. Supporting the Supply Chain Management on projects as well as leading and participating in supply chain projects as required.Responsibilities
- Lead day to day activities for clinical supply to patients for Sigilon
- Be point of contact for Clinical Operations and Clinical Research Organizations (CRO) for supply matters (e.g. supply timelines, shipments, etc). Represent Manufacturing and
Supply Chain on internal clinical study team meetings and CRO meetings - Generate and maintain patient demand forecast for ongoing and new programs/studies in coordination with Clinical Operations and New Product Planning
- Work with Clinical Operations to understand clinical enrollment projections and align coordinate production schedules with External Manufacturing for final product
- Management shipment of final product from manufacturing sites to clinical study sites. Ensure processes between Sigilon and couriers are functional and efficient
- Coordinate courier pickups, monitor and track shipments, and resolve any in transit issues
- Ensure seamless supply activities across shipment, Qualified Person (QP) releases, and site shipment receipt activities with External Manufacturing, Quality, and Clinical Operations
- Responsible for investigation of transit deviations and CAPA implementation in a timely compliant manner
- Develop supply strategies to maximize supply efficiency, while identifying risk and developing risk mitigation plans
- Support External Manufacturing as required on product and material shipment between Contract Manufacturing Organizations (CMO) as required
- Support in creation and maintenance of Standard Operating Procedures (SOP)
- Lead projects and process improvements within the Supply Chain
- Additional responsibilities as required
Requirements
- BS in the relevant Business, Chemistry, Biology or related field is required with minimum 6 years biotech/pharmaceutical Supply Chain. MBA/Masters Degree preferred
- Demonstrates a solid understanding of Supply Chain. Understands interdependencies of parts of supply chain and stakeholders. Uses industry knowledge to drive best-practices within company
- Demonstrated project leadership skills and ability to develop effective working processes and relationships with internal/external partners and cross-functional project teams
- Understand comprehensive global pharmaceutical regulatory requirements (e.g. cGMP, GDP, CFRs, Annex 13, ICH E6 (R2), etc)
- Experience in interacting with Health Authorities (e.g. inspections)
- Experience in deviation investigation and CAPA implementation
- Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills
- An energetic self-starter who is adept at multi-tasking, has a track record of productivity and capable of working both independently and as part of multiple collaborative teams
- Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs
- Travel up to 10%
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Sigilon Therapeutics is seeking a Scientist to join the Assays group, which develops and performs biological assays for multiple therapeutic programs across the company.
Responsibilities
- Independently develop and perform standardize protocols for quantifying and assessing the activity of therapeutic proteins, including ELISA / MSD, cell-based assays, and biochemical / enzymatic assays.
- Assess scientific literature in a variety of therapeutic areas to design experiments and develop / optimize assays.
- Analyze, interpret, and present experimental data in multidisciplinary team meetings.
- Write and review SOPs, study reports, posters / publications, and technical sections of regulatory filings.
- Coordinate with molecular / cell biology, engineering, and in vivo team members to ensure timely delivery of assay data.
- Manage projects with external labs and assay transfers.
- Review internally / externally-generated analytical data for accuracy.
- Maintain detailed records in electronic lab notebook and sample management system.
- Evaluate and facilitate adoption of new technology / equipment to expand the capabilities of the Assays group.
Requirements
- Ph.D. in biochemistry, cell biology, molecular biology, or related discipline.
- At least 2 years of experience in the pharmaceutical / biotechnology industry, specifically in developing bioassay protocols.
- Experience with cell and molecular biology techniques, including ELISA / MSD, Western blot, mammalian cell culture, and other gene / protein expression assays.
- Experience with plate-based readers and analysis software, such as SoftMax Pro, BioTek Gen5, GraphPad Prism, and Excel.
- Exceptional attention to detail, particularly as it relates to the accuracy and precision of assays.
- Experience with assay qualification and validation in a GLP environment is a plus.
- Ability to work effectively with minimal supervision after initial training.
- Ability to set priorities and multi-task activities to effectively manage workflows and deliverables.
- Strong team orientation, with excellent written and oral communication skills.
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Responsibilities:
· Manage activities of multidisciplinary product development teams to achieve project timelines, from feasibility/proposal stage through clinical development
· Generate and manage project timelines
· Collaborate with research, pre-clinical development, manufacturing, clinical, regulatory, and other functions to establish and support cross-functional project needs
· Identify program timeline, resource, budget, and key technical risks as well as mitigations
· Keep team members focused on highest value-driving activities to support go/no go decisions as quickly as feasible
· Identify, establish, and manage vendors to support project needs – manage contracting process with new vendors
· Track project progress and achievements – present on project status at regular intervals
· Work on multiple teams at one time
Requirements:
· A proven track record in the delivery of multiple large and complex development projects to time and budget within a regulated environment
· Experience generating and managing project timelines on development projects with considerable novel content
· Experience managing multidisciplinary/cross-functional teams
· A self-motivated team player who tackles challenges with creative and innovative solutions
· Enthusiastic about advanced therapeutic discovery and development
· Experience in taking a product from concept through to launch including scale-up and transfer to manufacture
· Excellent oral & written communication skills
· Experience in biologics or cell derived products is preferred
· Advanced degree (M.S./Ph.D.) within an engineering or scientific discipline is a plus
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Sigilon is seeking an Associate Project Manager/Project Manager to drive the overall success of our R&D programs and platform development. This person will join a highly motivated team in Cambridge, MA, and will work collaboratively with the program teams to plan, track and report the diverse activities of R&D including discovery, preclinical research, project strategy, and budgeting.
Responsibilities:
· Lead teams to milestones quickly with precision by defining optimal strategy for advancement of the project
· Ensure teams are constantly focused on “killer” experiments rather than non-value driving experiments
· Define milestones, critical path activities, timeline, risks, assumptions, mitigation plans, and budgets for proposal preparation
· Liaise directly with key stakeholders to understand their needs and constraints
· Manage projects from the proposal stage through commercialization
· Track technical and commercial progress and achievements
· Work on multiple teams at one time
· Setup project management tools and process to drive efficiency in projects
Requirements:
· Bachelor degree or an advanced degree within a scientific discipline
· A proven track record in the delivery of multiple large and complex development projects to time and budget within a regulated environment
· Experience managing risk and timeline on development projects with considerable novel content
· Experience managing multidisciplinary teams, often across different client sites and geographies
· Excellent oral & written communication skills
· A self-motivated team player attitude, who is highly proactive, accountable, and enthusiastic about drug discovery and development
· Prefer experience in taking a putative drug from concept through to launch including scale-up and transfer to manufacture
· Prefer experience in biologics or cell derived products
· Prefer experience in metabolic or rare diseases