Courage to create something that matters

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We are ONE.
We, TOGETHER, are Sigilon.

We care deeply about patients’ and caregivers’ struggles, stories, and triumphs.

We care about rigorous science addressing critical patient needs

Learn how we care

We strive to earn and keep the trust of patients, caregivers, and partners.

We respect each other, embrace diversity, and work as one team.

Learn how we trust

We are passionate about the impact of groundbreaking discoveries.

We dream big and don’t fear failure. We ask “What if we could…?”

Learn how we pioneer

We build value for patients and their families, clinicians, partners, and shareholders.

We make sure every experiment and decision counts.

Learn how we create

We visualize success and make it happen.

We operate with urgency; patients can’t wait.

Learn how we act

Always Growing

We are change-makers, and we never stop in our quest to advance therapies for patients in need. For us that takes a number of forms — we stay abreast of the most recent Sigilon science at our Sigilon Monthly Sessions, where a team member presents their findings and cross-pollination of ideas is encouraged; we also meet up informally, around the weekly Friday breakfast or in our collaboration hubs outside the lab. In this way, we’re always inspiring one another and advancing science that matters.

Never Losing Sight of Our Purpose

We’re at Sigilon to make a difference for patients, and that is front and center in our day to day work. We host patients and caregivers at our offices to learn more about the disease areas we aim to treat. And we stay engaged with the broader community, from organizing a fundraiser to send young people to the New England Hemophilia Association Family Camp, to sponsoring rare disease awareness efforts.

Enjoying Our Relationships

From our Sigilon running team to occasional yoga outings to escape rooms and offsite retreats, we really enjoy our teamwork in all forms. We are a close-knit team with an upbeat atmosphere, and it shows in our productive science — a true team effort.

Life at Sigilon

I love that we have a fast-paced scientific workplace but where people are so approachable and friendly.

Guillaume

Associate Director, Therapeutic Lead, Hemophilia

My favorite part of the culture at Sigilon is that there’s a balance, which I think is very important in a work environment. There’s a balance between making sure that the employee’s needs are met, but the science is still also a focus and priority.

Rupinderjit

Associate Scientist, Islet Cell Therapy

‘We Together’ is our motto, and there is a reason we selected that. We feel we cannot do anything alone; our science and our functions are so unique that there is no one person that knows everything, but if we put our minds and our hearts and our hands together, we can achieve a lot.

Vanya

Vice President, Head of Human Resources

I think teamwork is very important in the lab because we all are just resources. We can’t know everything, we can’t do everything, so the fact that everyone is there to help you, to contribute to your success, is very important here.

Shaleen

Senior Associate Scientist, Molecular Biology

Everybody’s just nice, smart and interesting to talk to. They’re all about the passion and trying to reach the end goal of helping people, and all of those aspects combined together make Sigilon a great place to work.

Olivia

Vice President, Head of Islet Cell Therapy Research

I think one of the things that’s exciting at Sigilon is that there’s a lot of different components of what we’re trying to do here. There’s always a lot of new learnings and developments that are coming out of the various teams that make up Sigilon.

Ryan

Senior Project Manager, Portfolio

We’ve created an environment here where people are collaborative and friendly, and it makes it enjoyable coming to work every day.

Justin

Senior Project Manager

Current openings

Sigilon Therapeutics is seeking a highly motivated Scientist with previous experience in cell biology and cell-engineering with a passion for innovation to develop novel cell-based therapies for treatment of hematological, lysosomal storage and immune diseases.

Responsibilities

· Work in a matrixed environment to generate, expand and provide engineered cell lines for pipeline programs and platform development efforts.

· Routinely perform molecular and cell biology techniques including PCR, restriction enzyme digests, Gibson and traditional cloning, vector/gene design, DNA sequencing, qPCR, ELISA and western blot

· Performing stable cell transfection, selection and characterization of engineered cell lines

· Plan, design and execute experiments to identify and validate strategies for improvement and expansion of Sigilon’s Shielded Therapeutics platform.

· Present results of experiments and findings in multidisciplinary team meetings

· Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects

· Participate in discussions on optimizing protocols, tools, programs and/or new methods for project advancement and make the approved changes

· Maintain quality standards to ensure engineered cell lines meet the needs of the in vivo and cell biology teams

· Tissue culture of primary cells and cell lines

· Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook

· Comply with standard laboratory practices and company policies

Requirements

· Ph.D. degree with a focus on molecular and cellular biology.

· Strong track record demonstrated by high-quality publications

· 1-3 years industry experience desirable

· Tissue culture, ELISA, flow cytometry and cell-based assays.

· Experience in molecular cloning and plasmid preparation, RNA isolation and cDNA synthesis for RT-PCR and quantitative PCR are a plus

· Outstanding interpersonal skills and established collaborative working habits.

· Excellent oral and written communication skills

· Must enjoy coming to work and having fun while creating therapies that improve the lives of patients

Apply Now
Reporting to the Vice President, Head of Finance, the Assistant Controller will be a key contributor in further developing the finance and accounting function with integrity and focus on supporting our rapid and dynamic growth. The successful candidate will be a motivated self-starter with a strong work ethic and the ability to work well and collaboratively in a team-oriented environment. The position requires a deadline-driven individual with attention to details who can handle confidential and sensitive information

Responsibilities

• Work with VP Finance to develop, implement and maintain systems, procedures and policies consistent with requirements of a public company, including design and implementation of internal controls

• Ensure that the company’s financial statements and other mandatory filings are of the highest standards of quality, GAAP compliant and useful to management and investors

• Work cross-functionally to ensure all accruals are complete and recorded timely

• Coordinate all monthly, quarterly, and year-end entries are complete and accurate

• Ensure that the close process is streamlined with clear roles and responsibilities of those involved are documented

• Guarantee the accurate compilation, reconciliations, analysis and reporting of accounting and financial data

• Implement accounting processes and routines necessary for future SEC reporting (Form 10-Q, 10-K, Form 8-K, S-3, S-8 and Section 16 reporting requirements)

• Manage and oversee the Procure-to-Pay process and systems with focus on the Accounts Payable function, including directing work of others

• Process weekly payment run from NetSuite

• Act as a liaison between the company, government and CPA auditors providing the required information and keeping proper documentation for historical purposes

• Responsible for coordination of the work performed by tax advisors, including tax provision and tax returns

• Prepare quarterly Audit Committee and Disclosure Committee materials

• Assist and/or manage and process bi-weekly payroll

• Act as administrator of 401(k) plan, and liaison to 401(k) providers

• Assist with press releases, including investor presentations

• Support the preparation of the annual budget and quarterly rolling forecasts

• Execute other financial, accouting or administrative duties as necessary

Qualifications

• Bachelors/Master’s degree in Accounting/Finance or equivalent

• CPA certification and experience with Big 4 or other public accounting firm preferred

• Strong technical accounting experience

• Experience using ERP systems, NetSuite preferred

• 8+ years of related experience, including 1+ years managerial experience is required

• Experience with the SEC compliance issues of a public company preferred

• High attention to detail with good organization skills

• Ability to multitask, work independently, and meet deadlines

• Experience in biotech industry

Apply Now
Responsibilities

Digital and Print Media:

· Support the Manager of Patient Advocacy in the design, analysis and review of patient centered materials, both digitally and in print

· Work cross functionally to manage Sigilon’s Social Media presence and create content across all social media channels.

· Research and analyze patient advocacy trends in order to develop and maintain best practices

Patient and Community Engagement

· Assist in developing relationships with local, national and international patient advocacy organizations, foundations, and other patient-focused groups and maintaining accurate contact lists

· Assist in coordinating and executing on site visits with external stakeholders, key patient opinion leaders, agencies, government and policy affairs and vendors.

· Increase awareness of Sigilon’s technology through partnerships with patient advocacy organizations, including their online and print publications.

· Support cross functionally in the development and roll out of Patient Advisory Boards and awareness of clinical trials, when applicable.

· Maintain detailed timelines and budgets for Patient Advocacy supported events

· Prepare for, attend and exhibit at Patient Advocacy events as needed

· Be point of contact with external vendors and our internal Accounts Payable department for patient advocacy events and materials

Sigilon Involvement:

· Coordinate onsite visits for Sigilon employee engagement

· Research and develop potential ideas for We Care and Sigilon employee engagement

· Update Sigilon Intranet with content when applicable

Requirements

· Bachelor’s Degree or equivalent experience

· Minimum one year industry experience preferred

· Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills

· An energetic self-starter who is adept at multi-tasking, has a track record of productivity and capable of working both independently and as part of multiple collaborative teams

· Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs

· Ability to travel as needed

Apply Now
As our lead programs advance into clinical development, Sigilon is looking for Upstream Process Development scientists to join the team responsible for enhancing and evolving the manufacturing process for Sigilon’s encapsulated allogeneic cell therapy platform. Key objectives will be to develop robust and scalable cell therapy bioprocesses and transfer these processes to contract manufacturing partners. Interpretation of scientific data, creation of scientific plans, proposals on process optimization, hands-on scientific experimentation, and technical presentations are expected. Strong communication skills and an ability to interact with cross-functional teams are required.

Responsibilities

· Design and execute Process Development laboratory studies that support the evaluation, development and implementation of new technologies for cell therapy manufacturing

· Perform hands-on lab-based activities in a cell culture lab, including analysis and communication of results to cross-functional teams

· Perform process or equipment analysis and trend process or equipment performance

· Provide process training to GMP personnel

· Support technology transfer and GMP manufacturing operations as needed

· Perform statistical analysis including design of experiments (DOEs) as appropriate

· Write and review technical documentation, technical SOPs, draft manufacturing batch records, technical reports and summary reports

· Support qualification and risk assessment activities for GMP implementation

Requirements

· BS in Biochemical Engineering, Chemical Engineering, Biomedical Engineering, Biotechnology or related discipline

· Cell therapy specific experience preferred

· Hands-on experience with process development including use of bioreactors and use of statistical design of experiments is required

· Strong analytical skills to perform statistical analysis as well as proficiency in statistical software (R, JMP, Minitab)

· Established cell culture lab techniques and aseptic processing in a BSC such as cell passaging, sampling, fluid handling, media formulation, managing reagents, and cryopreservation

· Mastery of scientific and engineering principles related to upstream bioprocessing including scale-up / scale-out approaches, hydrodynamics, mass transfer, and bioreactor design

Apply Now
Sigilon Therapeutics is seeking an individual with expertise in pharmaceutical/biotechnology quality assurance, excellent communication skills, and the ability to work in a highly interactive and matrixed environment. The incumbent will serve as integral member of the Quality Group, focusing on implementation, maintenance and oversight of QMS documentation, administration of the corporate training program, deviation and CAPA management, and internal auditing, This role will require daily interaction with stakeholders including but not limited to Chemistry, Biology, Clinical Operations, Contract Manufacturing Organizations (CMOs), Clinical Research Organizations (CROs), and External Testing Laboratories.

Presentation of written and oral summaries of progress in team meetings as well as to management is expected. Supporting Quality initiatives as well as leading and participating in Quality projects as required.

Responsibilities:
- Quality Management System (QMS) Documentation Oversight and Compliance
- Manage implementation, management, and maintenance for all QMS procedural documents for all operational departments and acquisitions including archive and electronic storage of original signature documents
- Initiate and drive to completion the review/revision of all QMS documents per plans and schedules
- Assume primary authorship or major contributor for specific procedural revisions as assigned
- Batch record and C of A review and release
- Administration of corporate training program (in collaboration with department heads) involves the following activities:
- In collaboration with department heads, monitor global compliance to Corporate Training Policy and implement needed corrective and preventive actions
- Maintain role-based definitions of training requirements, enroll staff in computer-based-training programs, track staff training compliance to completion
- Report and escalate training non-compliance to senior management as applicable
- Support audit requests for training records including review of training and ad hoc corrections to those requested records as necessary.
- Internal Audits
- Prepare, conduct, and produce reports for process audits of key Sigilon departments and workflows on a scheduled basis to confirm compliance with the established SOPs
- Such audits include but are not limited to Chemistry, Biology, Engineering, IT, Manufacturing. Ensure all findings are resolved effectively in a timely manner.
- External Audits
- Prepare, conduct, and produce reports for process audits of key Sigilon suppliers/vendors on a scheduled basis to confirm compliance to relevant global regulatory regulations,master and quality agreements
- Such audits include but are not limited to CROs, CMOs and External Testing Laboratories
- Ensure all findings are resolved effectively in a timely manner.
Requirements
- B.S./B.A. Degree in scientific discipline, with a minimum 3 years of previous experience in quality assurance and systems in an FDA regulated or similar environment preferred.
- Experience with electronic document management systems, quality management systems, and electronic learning management systems (LMS). Working knowledge of relevant industry and government regulations including: 21 CFR 11. cGMP, GDP, CFRs, Annex 13, ICH E6 (R2). Uses industry knowledge to drive best-practices within company
- Demonstrated project leadership skills and ability to develop effective working processes and relationships with internal/external partners and cross-functional project teams
- Understand comprehensive global pharmaceutical regulatory requirements (e.g. cGMP, GDP, CFRs, Annex 13, ICH E6 (R2), etc)
- Experience in interacting with Health and Regulatory Authorities (e.g. inspections)
- Experience in deviation investigation and CAPA implementation
- Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills
- An energetic self-starter who is adept at multi-tasking, has a track record of productivity and capable of working both independently and as part of multiple collaborative teams
- Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs
- Travel up to 10%
Special considerations:
- Candidate must possess effective communication skills, and proven abilities in interfacing with colleagues in a number of different departments and managing multiple projects/priorities. Must be methodical, well organized and detail oriented. Individual must be highly self-motivated, readily adaptable to a fast-paced, multidisciplinary team-based environment and capable of working autonomously with little direct supervision.
Apply Now
Sigilon Therapeutics is searching for an energized and highly motivated Scientist to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. The candidate should have experience with development of a cell therapy or a biologic product.

Responsibilities
- Oversee production and evaluation of therapeutic cells for preclinical studies
- Establishing SOPs for processes and assays for technology transfer to CMOs and CROs
- Design of study protocols, coordination of study execution, and writing and review of study reports for non-GLP and GLP nonclinical studies performed in house and at external CROs
- Writing and review of regulatory submissions
- Demonstrate understanding and application of relevant scientific literature to the design of experimental protocols
- Adept at organization and analysis of data sets for tracking and trending and statistical analyses
- Present results of experiments and findings in multidisciplinary team meetings
- Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects
- Comply with standard laboratory practices and company policies
Requirements
- Ph.D. in the biological sciences with minimum 10 years biotech/pharmaceutical experience developing a product
- Must have prior experience and proficiency with technical writing including SOPs, study protocols and reports, IACUC protocols, and regulatory submissions
- Knowledge of GMP and GLP guidelines
- Skills in MS Office (Word, PowerPoint, Excel, Outlook) and data analysis
- Ability to work and succeed within a matrixed organization
- Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills.
- Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs.
- Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
Apply Now
Sigilon Therapeutics is seeking an individual with expertise in gene/cell therapy clinical supply, excellent communication skills, and the ability to work in a highly interactive and matrixed environment. The incumbent will oversee day to day patient supply activities for Sigilon clinical trials; including planning and distribution of final products to clinical sites. This role will require daily interaction with stakeholders including but not limited to Clinical Operations, Clinical Research Organizations, Quality, and External Manufacturing. Presentation of
written and oral summaries of progress in team meetings as well as to management is expected. Supporting the Supply Chain Management on projects as well as leading and participating in supply chain projects as required.

Responsibilities
- Lead day to day activities for clinical supply to patients for Sigilon
- Be point of contact for Clinical Operations and Clinical Research Organizations (CRO) for supply matters (e.g. supply timelines, shipments, etc). Represent Manufacturing and
  Supply Chain on internal clinical study team meetings and CRO meetings
- Generate and maintain patient demand forecast for ongoing and new programs/studies in coordination with Clinical Operations and New Product Planning
- Work with Clinical Operations to understand clinical enrollment projections and align coordinate production schedules with External Manufacturing for final product
- Management shipment of final product from manufacturing sites to clinical study sites. Ensure processes between Sigilon and couriers are functional and efficient
- Coordinate courier pickups, monitor and track shipments, and resolve any in transit issues
- Ensure seamless supply activities across shipment, Qualified Person (QP) releases, and site shipment receipt activities with External Manufacturing, Quality, and Clinical Operations
- Responsible for investigation of transit deviations and CAPA implementation in a timely compliant manner
- Develop supply strategies to maximize supply efficiency, while identifying risk and developing risk mitigation plans
- Support External Manufacturing as required on product and material shipment between Contract Manufacturing Organizations (CMO) as required
- Support in creation and maintenance of Standard Operating Procedures (SOP)
- Lead projects and process improvements within the Supply Chain
- Additional responsibilities as required
Requirements
- BS in the relevant Business, Chemistry, Biology or related field is required with minimum 6 years biotech/pharmaceutical Supply Chain. MBA/Masters Degree preferred
- Demonstrates a solid understanding of Supply Chain. Understands interdependencies of parts of supply chain and stakeholders. Uses industry knowledge to drive best-practices within company
- Demonstrated project leadership skills and ability to develop effective working processes and relationships with internal/external partners and cross-functional project teams
- Understand comprehensive global pharmaceutical regulatory requirements (e.g. cGMP, GDP, CFRs, Annex 13, ICH E6 (R2), etc)
- Experience in interacting with Health Authorities (e.g. inspections)
- Experience in deviation investigation and CAPA implementation
- Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills
- An energetic self-starter who is adept at multi-tasking, has a track record of productivity and capable of working both independently and as part of multiple collaborative teams
- Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs
- Travel up to 10%
Apply Now
We are look for a motivated immunologist with a passion for innovation to develop novel technologies to optimize and regulate production of therapeutic proteins in vivo.

Responsibilities

· Spearhead and lead internal research projects to investigate immune mechanisms and novel disease applications of our cell therapy platform

· Present results of experiments and findings in multidisciplinary team meetings

· Conceive, design and implement novel cell-engineering technologies to regulate production of therapeutic proteins.

· Manage external projects with CROs and external collaborators.

· Work in a fast moving, highly interactive matrixed dynamic business environment and changing project portfolios

Requirements

· Ph.D. degree in Immunology

· Previous Industry experience would be a plus.

· Management experience desirable.

· Experience in tissue culture, cell-based assays and flow cytometry and other standard immunological assays.

· Outstanding interpersonal skills and established collaborative working habits.

· Excellent oral and written communication skills

· Must enjoy coming to work and having fun while creating therapies that improve the lives of patients

Apply Now