Courage to create something that matters

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We are ONE.
We, TOGETHER, are Sigilon.

We care deeply about patients’ and caregivers’ struggles, stories, and triumphs.

We care about rigorous science addressing critical patient needs

Learn how we care

We strive to earn and keep the trust of patients, caregivers, and partners.

We respect each other, embrace diversity, and work as one team.

Learn how we trust

We are passionate about the impact of groundbreaking discoveries.

We dream big and don’t fear failure. We ask “What if we could…?”

Learn how we pioneer

We build value for patients and their families, clinicians, partners, and shareholders.

We make sure every experiment and decision counts.

Learn how we create

We visualize success and make it happen.

We operate with urgency; patients can’t wait.

Learn how we act

Always Growing

We are change-makers, and we never stop in our quest to advance therapies for patients in need. For us that takes a number of forms — we stay abreast of the most recent Sigilon science at our Sigilon Monthly Sessions, where a team member presents their findings and cross-pollination of ideas is encouraged; we also meet up informally, around the weekly Friday breakfast or in our collaboration hubs outside the lab. In this way, we’re always inspiring one another and advancing science that matters.

Never Losing Sight of Our Purpose

We’re at Sigilon to make a difference for patients, and that is front and center in our day to day work. We host patients and caregivers at our offices to learn more about the disease areas we aim to treat. And we stay engaged with the broader community, from organizing a fundraiser to send young people to the New England Hemophilia Association Family Camp, to sponsoring rare disease awareness efforts.

Enjoying Our Relationships

From our Sigilon running team to occasional yoga outings to escape rooms and offsite retreats, we really enjoy our teamwork in all forms. We are a close-knit team with an upbeat atmosphere, and it shows in our productive science — a true team effort.

Life at Sigilon

My favorite part of the culture at Sigilon is that there’s a balance, which I think is very important in a work environment. There’s a balance between making sure that the employee’s needs are met, but the science is still also a focus and priority.

Rupinderjit

Associate Scientist, Islet Cell Therapy

‘We Together’ is our motto, and there is a reason we selected that. We feel we cannot do anything alone; our science and our functions are so unique that there is no one person that knows everything, but if we put our minds and our hearts and our hands together, we can achieve a lot.

Vanya

Vice President, Head of Human Resources

I think teamwork is very important in the lab because we all are just resources. We can’t know everything, we can’t do everything, so the fact that everyone is there to help you, to contribute to your success, is very important here.

Shaleen

Senior Associate Scientist, Molecular Biology

Everybody’s just nice, smart and interesting to talk to. They’re all about the passion and trying to reach the end goal of helping people, and all of those aspects combined together make Sigilon a great place to work.

Olivia

Vice President, Head of Islet Cell Therapy Research

I think one of the things that’s exciting at Sigilon is that there’s a lot of different components of what we’re trying to do here. There’s always a lot of new learnings and developments that are coming out of the various teams that make up Sigilon.

Ryan

Senior Project Manager, Portfolio

We’ve created an environment here where people are collaborative and friendly, and it makes it enjoyable coming to work every day.

Justin

Senior Project Manager

Current openings

Sigilon Therapeutics is searching for an energized and highly motivated Associate Scientist to be part of a team focused on developing a novel therapeutic product for Rare Disease utilizing Sigilon’s Afibromer™ technology. The candidate should have experience in rare disease, including cell culture experience, functional cellular analyses, sample preparation for analyses of samples from in vivo/ in vitro work.
Responsibilities
Tissue culture of primary cells and recombinant cell lines
Perform and interpret data from enzymatic, cell-based assays and molecular biology assays
Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook
Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects
Comply with standard laboratory practices and company policies
Requirements
BS or MS degree in the biological sciences
Sample preparation and analysis from in vitro and in vivo is a plus
Outstanding interpersonal skills and established collaborative working habits
Skills in MS Office: Word, PowerPoint, Excel, Outlook
Ability to work and succeed within a matrixed organization
Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
Apply Now
We are look for a motivated immunologist with a passion for innovation to develop novel cell-based therapies for the treatment of immune-mediated diseases.
Responsibilities
- Conceive, design and conduct PoC experiments to generate data which support PK, efficacy & safety of therapeutic products in preclinical models of inflammatory disease.
- Develop and independently execute immunological and biochemical assays needed to determine immunogenicity.
- Conducting ex vivo experiments to assess function of different immune cell types, such as T cells and NK cells or dendritic cells
- Development and execution of human primary immune cell-based assays for determining activity of therapeutic proteins
- Critically analyze and interpret data, able to prioritize experiments and design follow-up experiments leading to project advancement.
- Manage external projects with CROs and external collaborators.
- Regularly communicate and present results to leadership teams
- Open approach, ability, and eagerness to learn novel techniques or analysis tools based on project needs.
- Contribute to optimizing protocols, tools, and/or development of new methods.
- Work collaboratively in a fast moving, highly interactive matrixed dynamic business environment and changing project portfolios
- Maintain familiarity with scientific and technical literature pertinent to the projects
Requirements
- Ph.D. degree or post-doctoral training in Immunology
- Post-doctoral or Industry experience highly desirable
- Proven track record exemplified by high-quality publications
- Expertise in cell engineering
- Experience in standard immunology assays such as flow cytometry, ELISA etc…
- Experience in executing in vivo studies in pre-clinical models of inflammatory / autoimmune diseases.
- Outstanding interpersonal skills and established collaborative working habits.
- Excellent oral and written communication skills
- Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
Apply Now
Sigilon is looking for an experienced process development scientist to join our team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. Key objectives will be to develop robust and scalable cell therapy bioprocesses and transfer these processes to contract manufacturing partners.
KEY RESPONSIBILITIES
· Execute manufacturing process development to scale up iPSC expansion, differentiation
and encapsulation in collaboration with biology and engineering development teams.
· Development of SOPs, batch records and training documents and tech transfer processes to manufacturing partners
· Analyze process data to identify trends and to evaluate and identify critical process
parameters
· Collaborate with Quality, Supply Chain and Regulatory functions to ensure processes,
reagents and ancillary materials are aligned with cGMP and regulatory
requirements.
· Contribute to authoring and assembling CMC sections of regulatory filing(s) as needed.
· Periodically traveling to CMOs, CROs and collaboration partners as needed for training or
Person in Plant oversight.
PROFESSIONAL EXPERIENCE/QUALIFICATIONS
· BS/MS in chemistry, biology, engineering or a related discipline with 5+ years
biologics and/or cell therapy process development experience or Ph.D. with 2
years relevant experience
· Significant experience with a variety of mammalian cell culture technologies and
operations, pluripotent stem cell therapy specific experience preferred,
including industry experience with cell therapy process development desired
· Hands-on experience with Quality by Design – Design of Experiments (DoE’s) and how it
can be applied to cell therapy bioprocessing
· Strong analytical skills to perform statistical analysis as well as proficiency in
statistical software (R, JMP, Minitab)
· Breadth of knowledge across bioprocessing technologies, cell characterization method
development, GLP/GMP experience, strongly desired
· Working knowledge of biologics CMC regulations and cGMP requirements, as well as,
experience in supporting regulatory filings
· Demonstrated success in delivery of a complex therapeutic program into the clinic desired
· Innovative, critical and creative thinker, unafraid to propose aggressive solutions to
complex problems
· Excellent communication and collaboration skills, comfortable working in a matrix
environment

Apply Now
Sigilon is looking for an experienced process development scientist to join our team focused on our platform of novel therapies utilizing Sigilon’s Afibromer™ technology. Key objectives will be to develop robust and scalable cell therapy
bioprocesses with an emphasis on supporting regulatory filings and tech transfer to external manufacturing partners.

KEY RESPONSIBILITIES

· Execute manufacturing process development to scale up expansion of adhesion-dependent
cells in collaboration with biology and engineering development teams

· Development of SOPs, batch records and training documents and tech transfer processes to
manufacturing partners

· Design experiments and analyze data to ensure process robustness

· Collaborate with Quality, Supply Chain and Regulatory functions to ensure processes,
reagents and ancillary materials are aligned with cGMP and regulatory
requirements

· Contribute to authoring and assembling CMC sections of regulatory filing(s) as needed

· Manage sample submission, report writing, and proper documentation for in vivo
studies

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

· BS/MS in chemistry, biology, or engineering or a related discipline with 5+ years
biologics and/or cell therapy process development experience or Ph.D. with 2
years relevant experience

· Strong background in statistical analysis and familiarity with statistical software
packages (Prism, Matlab, R, JMP, or similar)

· Good mammalian cell culture technique and aseptic processing, preferably with
experience working with a variety of cell culture equipment such as cell
counters, metabolite analyzers, and similar

· Experience in cryopreservation is a plus

· Experience with project management is a plus

· Excellent communication and collaboration skills, comfortable working in a matrix
environment

· Working familiarity with cGMP requirements

Apply Now
Sigilon Therapeutics is looking for an experienced process development scientist to join the team responsible for enhancing and evolving the manufacturing process for Sigilon’s encapsulated allogeneic cell therapy platform. Key objectives will be to develop robust and scalable cell therapy bioprocesses and transfer these processes to contract manufacturing partners.
KEY RESPONSIBILITIES
- Design and execute process development laboratory studies that support the evaluation, development and implementation of new technologies for cell therapy manufacturing.
- Perform hands-on lab-based activities in a cell culture lab, including analysis and communication of results to cross-functional teams.
- Perform process or equipment analysis and trend process or equipment performance.
- Provide process training to GMP personnel.
- Support technology transfer and GMP manufacturing operations as needed.
- Perform statistical analysis including design of experiments (DOEs) as appropriate.
- Write and review technical documentation, technical SOPs, draft manufacturing batch records, technical reports and summary reports.
- Support qualification and risk assessment activities for GMP implementation.
PROFESSIONAL EXPERIENCE/QUALIFICATIONS
- BS in Biochemical Engineering, Chemical Engineering, Biomedical Engineering, Biotechnology or related discipline with 3+ years biologics manufacturing & process development experience required. Cell therapy specific experience preferred
- Strong analytical skills to perform statistical analysis as well as proficiency in statistical software (R, JMP, Minitab)
- Established cell culture lab techniques and aseptic processing in a BSC such as cell passaging, sampling, fluid handling, media formulation, managing reagents, and cryopreservation.
- Mastery of scientific and engineering principles related to upstream bioprocessing including scale-up / scale-out approaches, hydrodynamics, mass transfer, and bioreactor design and monitoring is desired
- Practical knowledge of cGMP manufacturing and regulatory regulations and requirements for pharmaceuticals and devices.
Apply Now
Sigilon Therapeutics is searching for an energized and highly motivated Sr. Associate Scientist to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. The candidate should have experience with tissue culture of cell lines and with cell and molecular biology assays.
Responsibilities
Tissue culture of cell lines and pluripotent stem cell lines
Reagent preparation, lab organization and daily maintenance of long-term experiments
Perform cell-based and molecular biology assays, including cell viability, flow cytometry, qPCR, and functional assays
Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook
Present results of experiments and findings in multidisciplinary team meetings
Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects
Comply with standard laboratory practices and company policies
Requirements
Sc. with 3+ years industry experience or M.Sc. degree with 2+ years industry experience with a focus on biology, molecular biology or cell biology
At least 2 years laboratory experience in industry or academia desirable
Experience in tissue culture and cell-based and molecular biology assays, e.g. qPCR, immunohistochemistry, ELISA, and flow cytometry a plus
Organization, attention to detail, willingness to learn new techniques and scientific curiosity a must
Outstanding interpersonal skills and established collaborative working habits
Excellent oral and written communication skills
Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
Apply Now
The employee will lead cross functional teams to drive development programs from research through commercial launch to meet the company’s goals and effectively treat patients. The successful candidate will have a strong knowledge of product development, regulatory requirements, preclinical studies, and manufacturing preferably for cell-based therapy. An ability to think outside of the box and experience with combination products will benefit the candidate for this role. The candidate will also have an excellent execution track record on for on-time delivery, as well as demonstrable strategic insight, creativity for overcoming challenges, and program prioritization skills. This role will require daily interaction with stakeholders in program management, engineering, biology, non-clinical, quality, regulatory, manufacturing, and clinical teams as well as external teams. Presentation of written and oral summaries of progress to senior management and expert consultants will be required.

Responsibilities:

· Lead cross functional team to drive development programs exiting research through to commercial launch

· Lead multi-disciplinary project teams through demonstrating an in-depth knowledge of biologic/combination product development, excellent interpersonal communication skills, leadership skills, and influencing skills

· Ensure transparency throughout development by securing project resources and communicate gaps, identify risks and mitigate/communicate to management, and define critical path items and alert team to changes to critical path items

· Proactively anticipate issues, challenges, and assumptions as well as identify contingencies or creative opportunities to circumvent potential delays

· Guide the team in appropriate decision-making through analyzing options and reviewing implications

· Develop and maintain timelines in partnership with program management for development programs

· Partner with technical leads/SMEs to establish requirements for program success

· Coordinate with nonclinical team for execution of all studies required for regulatory filings

· Work with engineering and encapsulation team to push readiness of product enabling technologies such as packaging, stability, delivery and surgical technique development

· Synchronize with clinical team to ensure readiness of program for trial initiation

· Maintain documentation and write reports to support quality requirements, regulatory filings, IP as needed

Requirements/experience with:

· At least 10+ years of relevant industry experience in product development and program management

· MS or PhD preferred; biomedical engineering, biology, program management, or similar field

· Strategic thinker, able to assess the program needs and prioritize according to corporate timelines

· People leadership and mentorship capabilities

· Experience with reparation of FDA submission documents, FDA interactions

· Experience in design, optimization, testing, data analysis and validation protocols

· Outstanding interpersonal skills and established collaborative working habits

· Excellent oral and written communication skills

· Must be available to start work in the immediate future; authorization to work in the US

Apply Now
Responsibilities:

Perform preclinical in vivo studies in rodents, which requires surgery, necropsy, test article administration and blood and tissue collection for analysis

Understand and ensure compliance with IACUC protocols and EHS regulations

In a matrix environment, collaborate with team members and coordinate assigned activities
with other teams to ensure timely completion

Make observations, evaluate data, interpret results and document in a
well-maintained laboratory notebook and study reports in timely fashion

Comply with standard laboratory practices and company policies

Work with team leads to evaluate histopathology assays and perform imaging for internal
programs

Participate in discussions to optimize protocols, tools, or methods for project advancement

Apply relevant scientific literature to the design of experimental protocols

Present study results of experiments and findings in multidisciplinary team meetings

Requirements:

B.Sc. degree in biology or similar degree

2+ years industry experience working in a vivarium is desirable

Proficiency in rodent handling, blood collection, tissue harvesting and processing of
biological samples for ex vivo analysis is required

Experience in rodent surgery, especially laparotomy is highly desirable

Experience in histopathological techniques such as tissue sectioning, staining, and microscopy imaging is a plus

Outstanding sense of urgency, interpersonal skills and established collaborative working habits in a dynamic,
matrixed environment

Excellent oral and written communication skills and time management

Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
Apply Now