Courage to create something that matters

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We are ONE.
We, TOGETHER, are Sigilon.

We care deeply about patients’ and caregivers’ struggles, stories, and triumphs.

We care about rigorous science addressing critical patient needs

Learn how we care

We strive to earn and keep the trust of patients, caregivers, and partners.

We respect each other, embrace diversity, and work as one team.

Learn how we trust

We are passionate about the impact of groundbreaking discoveries.

We dream big and don’t fear failure. We ask “What if we could…?”

Learn how we pioneer

We build value for patients and their families, clinicians, partners, and shareholders.

We make sure every experiment and decision counts.

Learn how we create

We visualize success and make it happen.

We operate with urgency; patients can’t wait.

Learn how we act

Always Growing

We are change-makers, and we never stop in our quest to advance therapies for patients in need. For us that takes a number of forms — we stay abreast of the most recent Sigilon science at our Sigilon Monthly Sessions, where a team member presents their findings and cross-pollination of ideas is encouraged; we also meet up informally, around the weekly Friday breakfast or in our collaboration hubs outside the lab. In this way, we’re always inspiring one another and advancing science that matters.

Never Losing Sight of Our Purpose

We’re at Sigilon to make a difference for patients, and that is front and center in our day to day work. We host patients and caregivers at our offices to learn more about the disease areas we aim to treat. And we stay engaged with the broader community, from organizing a fundraiser to send young people to the New England Hemophilia Association Family Camp, to sponsoring rare disease awareness efforts.

Enjoying Our Relationships

From our Sigilon running team to occasional yoga outings to escape rooms and offsite retreats, we really enjoy our teamwork in all forms. We are a close-knit team with an upbeat atmosphere, and it shows in our productive science — a true team effort.

Life at Sigilon

I love that we have a fast-paced scientific workplace but where people are so approachable and friendly.

Guillaume

Associate Director, Therapeutic Lead, Hemophilia

My favorite part of the culture at Sigilon is that there’s a balance, which I think is very important in a work environment. There’s a balance between making sure that the employee’s needs are met, but the science is still also a focus and priority.

Rupinderjit

Associate Scientist, Islet Cell Therapy

‘We Together’ is our motto, and there is a reason we selected that. We feel we cannot do anything alone; our science and our functions are so unique that there is no one person that knows everything, but if we put our minds and our hearts and our hands together, we can achieve a lot.

Vanya

Vice President, Head of Human Resources

I think teamwork is very important in the lab because we all are just resources. We can’t know everything, we can’t do everything, so the fact that everyone is there to help you, to contribute to your success, is very important here.

Shaleen

Senior Associate Scientist, Molecular Biology

Everybody’s just nice, smart and interesting to talk to. They’re all about the passion and trying to reach the end goal of helping people, and all of those aspects combined together make Sigilon a great place to work.

Olivia

Vice President, Head of Islet Cell Therapy Research

I think one of the things that’s exciting at Sigilon is that there’s a lot of different components of what we’re trying to do here. There’s always a lot of new learnings and developments that are coming out of the various teams that make up Sigilon.

Ryan

Senior Project Manager, Portfolio

We’ve created an environment here where people are collaborative and friendly, and it makes it enjoyable coming to work every day.

Justin

Senior Project Manager

Current openings

Director/Sr. Director, Preclinical Development Program Lead

The employee will lead cross functional teams to drive development programs from research through commercial launch to meet the company’s goals and effectively treat patients. The successful candidate will have a strong knowledge of product development, regulatory requirements, preclinical studies, and manufacturing preferably for cell-based therapy. An ability to think outside of the box and experience with combination products will benefit the candidate for this role. The candidate will also have an excellent execution track record on for on-time delivery, as well as demonstrable strategic insight, creativity for overcoming challenges, and program prioritization skills. This role will require daily interaction with stakeholders in program management, engineering, biology, non-clinical, quality, regulatory, manufacturing, and clinical teams as well as external teams. Presentation of written and oral summaries of progress to senior management and expert consultants will be required.

Responsibilities:
- Lead cross functional team to drive development programs exiting research through to commercial launch
- Lead multi-disciplinary project teams through demonstrating an in-depth knowledge of biologic/combination product development, excellent interpersonal communication skills, leadership skills, and influencing skills
- Ensure transparency throughout development by securing project resources and communicate gaps, identify risks and mitigate/communicate to management, and define critical path items and alert team to changes to critical path items
- Proactively anticipate issues, challenges, and assumptions as well as identify contingencies or creative opportunities to circumvent potential delays
- Guide the team in appropriate decision-making through analyzing options and reviewing implications
- Develop and maintain timelines in partnership with program management for development programs
- Partner with technical leads/SMEs to establish requirements for program success
- Coordinate with nonclinical team for execution of all studies required for regulatory filings
- Work with engineering and encapsulation team to push readiness of product enabling technologies such as packaging, stability, delivery and surgical technique development
- Synchronize with clinical team to ensure readiness of program for trial initiation
- Maintain documentation and write reports to support quality requirements, regulatory filings, IP as needed
Requirements/experience with:
- At least 10 years of relevant industry experience in product development and program management
- MS or PhD preferred; biomedical engineering, biology, program management, or similar field
- Strategic thinker, able to assess the program needs and prioritize according to corporate timelines
- People leadership and mentorship capabilities
- Experience with reparation of FDA submission documents, FDA interactions
- Experience in design, optimization, testing, data analysis and validation protocols
- Outstanding interpersonal skills and established collaborative working habits
- Excellent oral and written communication skills
Apply Now
Sigilon Therapeutics is searching for an energized and highly motivated Scientist to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. The candidate should have experience with development of a cell therapy or a biologic product.

Responsibilities
- Oversee production and evaluation of therapeutic cells for preclinical studies
- Establishing SOPs for processes and assays for technology transfer to CMOs and CROs
- Design of study protocols, coordination of study execution, and writing and review of study reports for non-GLP and GLP nonclinical studies performed in house and at external CROs
- Writing and review of regulatory submissions
- Demonstrate understanding and application of relevant scientific literature to the design of experimental protocols
- Adept at organization and analysis of data sets for tracking and trending and statistical analyses
- Present results of experiments and findings in multidisciplinary team meetings
- Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects
- Comply with standard laboratory practices and company policies
Requirements
- Ph.D. in the biological sciences with minimum 10 years biotech/pharmaceutical experience developing a product
- Must have prior experience and proficiency with technical writing including SOPs, study protocols and reports, IACUC protocols, and regulatory submissions
- Knowledge of GMP and GLP guidelines
- Skills in MS Office (Word, PowerPoint, Excel, Outlook) and data analysis
- Ability to work and succeed within a matrixed organization
- Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills.
- Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs.
- Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
Apply Now