Courage to create something that matters

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We are ONE.
We, TOGETHER, are Sigilon.

We care deeply about patients’ and caregivers’ struggles, stories, and triumphs.

We care about rigorous science addressing critical patient needs

We strive to earn and keep the trust of patients, caregivers, and partners.

We respect each other, embrace diversity, and work as one team.

We are passionate about the impact of groundbreaking discoveries.

We dream big and don’t fear failure. We ask “What if we could…?”

We build value for patients and their families, clinicians, partners, and shareholders.

We make sure every experiment and decision counts.

We visualize success and make it happen.

We operate with urgency; patients can’t wait.

Always Growing

We are change-makers, and we never stop in our quest to advance therapies for patients in need. For us that takes a number of forms — we stay abreast of the most recent Sigilon science at our Sigilon Monthly Sessions, where a team member presents their findings and cross-pollination of ideas is encouraged; we also meet up informally, around the weekly Friday breakfast or in our collaboration hubs outside the lab. In this way, we’re always inspiring one another and advancing science that matters.

Never Losing Sight of Our Purpose

We’re at Sigilon to make a difference for patients, and that is front and center in our day to day work. We host patients and caregivers at our offices to learn more about the disease areas we aim to treat. And we stay engaged with the broader community, from organizing a fundraiser to send young people to the New England Hemophilia Association Family Camp, to sponsoring rare disease awareness efforts.

Enjoying Our Relationships

From our Sigilon running team to occasional yoga outings to escape rooms and offsite retreats, we really enjoy our teamwork in all forms. We are a close-knit team with an upbeat atmosphere, and it shows in our productive science — a true team effort.

Life at Sigilon

We have an amazingly collaborative team; we really like each other and this makes working together enjoyable.

Lori

Office Manager/Executive Assistant

I love that we have a fast-paced scientific workplace but where people are so approachable and friendly.

Guillaume

Associate Director

Current openings

We are look for a motivated immunologist with a passion for innovation to develop novel technologies to optimize and regulate production of therapeutic proteins in vivo.

Responsibilities
- Conceive, design and conduct experiments to monitor and modulate immune responses to implanted cells and their products
- Tissue culture of primary cells and cell lines at scales from cloning to bulk production
- Stable transfection and selection of engineered cell lines
- Manage external projects with CROs and external collaborators.
- Work in a fast moving, highly interactive matrixed dynamic business environment and changing project
  portfolios
- Participate in discussions on optimizing protocols, tools, programs and/or new methods for
  project advancement and make the approved changes
- Present results of experiments and findings in multidisciplinary team meetings
Requirements
- Ph.D. degree in Immunology
- Minimum of 2 years industry experience required.
- Experience in standard immunology assays such as flow cytometry
- Outstanding interpersonal skills and established collaborative working habits.
- Excellent oral and written communication skills
- Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
Apply Now
Responsibilities:

· Encapsulation of cells in novel biopolymer systems

· Maintenance and setting up of biopolymer device encapsulation systems

· Establishing protocols and SOPs for encapsulation procedure

· Work in a matrixed environment to ensure biomaterials meet the needs of the in vivo and cell biology teams

· With increasing independence, plan, design and execute of a series of experiments that provide the research findings necessary for the completion of an assigned project

· Demonstrate understanding and application of relevant scientific literature to the design of experimental protocols

· Participate in discussions on optimizing protocols, tools, programs and/or new methods for project advancement and make the approved changes

· Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook

· Present results of experiments and findings in multidisciplinary team meetings

· Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects

· Comply with standard laboratory practices and company policies

Requirements:

· B.Sc. or M.Sc. degree with a focus on biomaterials, engineering, biochemistry or biology

·0-2 years industry experience desirable

· Experience in biomaterials, tissue engineering, microfluidic systems integration, or working in a regulated environment desirable

· Outstanding interpersonal skills and established collaborative working habits.

· Excellent oral and written communication skills

· Must enjoy coming to work and having fun while creating therapies that improve patient lives

Apply Now
Sigilon Therapeutics is seeking an individual with broad expertise in in-vivo and translational biology, excellent communication
skills, and the ability to work in a highly interactive and matrixed environment.

Responsibilities:

• The position is a hands-on, laboratory-based role.

• Conduct in-vivo studies in rodents which requires surgical implantation, dosing, necropsy, blood and tissue collection

• Coordinate in vivo pharmacology research in a matrixed environment, as well as external academic collaborations and an extensive network of CROs

• Interprets data independently, identifies complex technical issues, and implements solutions under supervision

• Supports technology transfer through rigorous documentation, writing and consolidating technical documents.

• Conduct literature research and independently develop disease or surgical models

Requirements:

• B.Sc., M.Sc. in biology or similar degree with minimum 5 years industry experience

• Experience working with CROs to carry out pharmacology, toxicology and PK/PD studies

• Must have prior experience and proficiency in drug substance administration, blood collection, tissue harvesting and processing of biological samples

• Experience with rodent surgery is a plus

• Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills

• An energetic self-starter who is adept at multi-tasking, has a track record of productivity and capable of working both independently and as part of multiple collaborative teams

• Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs

Apply Now
Sigilon Therapeutics is seeking an individual with broad expertise in in-vivo and translational biology, excellent communication
skills, and the ability to work in a highly interactive and matrixed environment.

Responsibilities:

• The position is a 70% hands-on, laboratory-based role.

• Demonstrate understanding and application of relevant scientific literature to the design of experimental protocols, work with therapeutic leads to develop disease or surgical models

• Establish study protocols, IACUC protocols, internal SOP

• Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook, authoring study reports

• Present results of experiments and findings in multidisciplinary team meetings

• Coordinate in vivo research with other teams as necessary to ensure the completion of the team’s research projects

• Conduct and coordinate in vivo research in external academic collaborations and an extensive network of CROs

• Conduct hands-on in-vivo studies in rodents which requires surgical implantation, dosing, necropsy, blood and tissue collection

• Comply with standard laboratory practices and company policies

Requirements:

• Ph. D in biological sciences or M.Sc. with a minimum of 5 years industry experience.

• Experience working with CROs to carry out pharmacology, toxicology and PK/PD studies

• Must have prior experience and proficiency in drug substance administration, blood collection, tissue harvesting and processing of biological samples

• Experience with rodent and large animal surgery is a plus

• Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills

• An energetic self-starter who is adept at multi-tasking, has a track record of productivity and capable of working both independently and as part of multiple collaborative teams

• Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs

Apply Now
The intern will be responsible for performing methods to develop and characterize devices and/or delivery methods. The successful candidate will also assist in the development and characterization of biomaterial-based tissue scaffolds. This role will require daily interaction with stake holders in engineering, biology, in vivo, regulatory, and clinical teams. Presentation of written and oral summaries of progress in team meetings as well as to management is expected. This employee will operate a diverse array of development,
manufacturing, and analytical equipment and maintain a safe laboratory environment.

Responsibilities:

· Design and perform experiments with biomaterials and biomaterial treatments

· Evaluate surface characteristics via known assays

· Develop assays for material characterization

· Perform or participate in biological assay completion to determine the effects of biomaterial treatments

· Assess data, develop logical next steps, and present to science leadership

· Participate in regulatory document preparation

Requirements/experience with:

· Currently pursing PhD in mechanical or biomedical engineering or closely related field

· Understanding of medical device design, biomaterials, and regulatory approval processes

· Familiarity with various implantable biomaterials, and their properties and characterization

· Understanding of sterilization methods

· Outstanding interpersonal skills and established collaborative working habits

· Excellent oral and written communication skills

· Must be available to start work in the immediate future

· Must have authorization to work in the United States

Apply Now
R&D Engineer

The incumbent will be responsible for developing and performing methods to characterize devices and/or delivery methods. The successful candidate will also assist in the development and characterization of biomaterial-based tissue scaffolds. This role will require daily interaction with stake holders in engineering, biology, in vivo, regulatory, and clinical teams. Presentation of written and oral summaries of progress in team meetings as well as to management is expected. This employee will operate a diverse array of development, manufacturing, and analytical equipment and maintain a safe laboratory environment.

Responsibilities:

· Evaluate user requirements for surgical delivery devices and develop instruments to fulfill those requirements

· Develop testing methods to ensure that user requirements are fulfilled

· Develop method of manufacture, packaging, sterilization, and validation of device in partnership with internal team and external vendors in accordance with current regulations

· Help identify external vendors for all processes needed to provide devices to clinicians

· Complete the design control process for a variety of programs

· Maintain documentation and write reports to support IP, design control, and regulatory filings

· Maintain close communication with surgical, engineering, and project management teams to ensure timely completion of milestones

Requirements/experience with:

· Degree in mechanical or biomedical engineering
- Ph.D. with 4+ years of industry experience
- M.S. with 6+ years of industry experience
- B.S. with 8+ years of industry experience
· Leadership of medical device design and participation in regulatory approval documentation preparation

· Preparation of design control documentation, leading design reviews

· Familiarity with various implantable biomaterials, and their properties and characterization

· Experience with medical device manufacturing processes

· Packaging design and testing

· Sterilization methods and validations

· Outstanding interpersonal skills and established collaborative working habits

· Excellent oral and written communication skills

· Must be available to start work in the immediate future

· Must have authorization to work in the United States
Apply Now
The successful candidate will be a seasoned administrative professional, ideally with experience in a rapidly growing start-up environment preferably, in a biotechnology company.

Responsibilities
- Support Chief Financial Officer and another c level suite member
- Assist the Leadership of a new division within Sigilon with scheduling and logistics of internal and external meetings and events including agenda preparation, travel and other logistics planning, and Sigilon executive internal and external communications
- Build effective relationships with counter-parts in Sigilon existing and potential partner organizations to enable effective prioritization and scheduling of multiple meetings
- Collect and manage important physical and digital division documents, both internal and external.
- Ability to organize a daily workload by priorities and be proactive in attending to those priorities
- Manage and update important informational documents with external parties
- Provide high quality support to assigned members, anticipate needs and foster positive culture
- Uphold a strict level of confidentiality
- Various other duties and tasks as needed
Qualifications
- 5+ years of experience as a Sr. Admin or EA supporting a number of senior level leaders
- Bachelor’s Degree or equivalent required
- Strong organizational, interpersonal and problem-solving skills
- Ability to be discrete with confidential information
- Ability to communicate clearly, both verbally and in writing
- Technically savvy in use of various communication platforms and apps
- Proficient with Microsoft Office suite
Apply Now