Courage to create something that matters

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We are ONE.
We, TOGETHER, are Sigilon.

We care deeply about patients’ and caregivers’ struggles, stories, and triumphs.

We care about rigorous science addressing critical patient needs

We strive to earn and keep the trust of patients, caregivers, and partners.

We respect each other, embrace diversity, and work as one team.

We are passionate about the impact of groundbreaking discoveries.

We dream big and don’t fear failure. We ask “What if we could…?”

We build value for patients and their families, clinicians, partners, and shareholders.

We make sure every experiment and decision counts.

We visualize success and make it happen.

We operate with urgency; patients can’t wait.

Always Growing

We are change-makers, and we never stop in our quest to advance therapies for patients in need. For us that takes a number of forms — we stay abreast of the most recent Sigilon science at our Sigilon Monthly Sessions, where a team member presents their findings and cross-pollination of ideas is encouraged; we also meet up informally, around the weekly Friday breakfast or in our collaboration hubs outside the lab. In this way, we’re always inspiring one another and advancing science that matters.

Never Losing Sight of Our Purpose

We’re at Sigilon to make a difference for patients, and that is front and center in our day to day work. We host patients and caregivers at our offices to learn more about the disease areas we aim to treat. And we stay engaged with the broader community, from organizing a fundraiser to send young people to the New England Hemophilia Association Family Camp, to sponsoring rare disease awareness efforts.

Enjoying Our Relationships

From our Sigilon running team to occasional yoga outings to escape rooms and offsite retreats, we really enjoy our teamwork in all forms. We are a close-knit team with an upbeat atmosphere, and it shows in our productive science — a true team effort.

Life at Sigilon

We have an amazingly collaborative team; we really like each other and this makes working together enjoyable.

Lori

Office Manager/Executive Assistant

I love that we have a fast-paced scientific workplace but where people are so approachable and friendly.

Guillaume

Associate Director, Therapeutic Lead, Hemophilia

My favorite part of the culture at Sigilon is that there’s a balance, which I think is very important in a work environment. There’s a balance between making sure that the employee’s needs are met, but the science is still also a focus and priority.

Rupinderjit

Associate Scientist, Islet Cell Therapy

‘We Together’ is our motto, and there is a reason we selected that. We feel we cannot do anything alone; our science and our functions are so unique that there is no one person that knows everything, but if we put our minds and our hearts and our hands together, we can achieve a lot.

Vanya

Vice President, Head of Human Resources

I think teamwork is very important in the lab because we all are just resources. We can’t know everything, we can’t do everything, so the fact that everyone is there to help you, to contribute to your success, is very important here.

Shaleen

Senior Associate Scientist, Molecular Biology

Everybody’s just nice, smart and interesting to talk to. They’re all about the passion and trying to reach the end goal of helping people, and all of those aspects combined together make Sigilon a great place to work.

Olivia

Vice President, Head of Islet Cell Therapy Research

I think one of the things that’s exciting at Sigilon is that there’s a lot of different components of what we’re trying to do here. There’s always a lot of new learnings and developments that are coming out of the various teams that make up Sigilon.

Ryan

Senior Project Manager, Portfolio

We’ve created an environment here where people are collaborative and friendly, and it makes it enjoyable coming to work every day.

Justin

Senior Project Manager

Current openings

  • Sigilon Therapeutics is seeking an individual with broad expertise in pharmaceutical Process Development, excellent communication skills, and the ability to work in a highly interactive and matrixed environment. The incumbent will oversee the aspects of scientific Process Development activities conducted internally and at Contract Manufacturing Organizations (CMOs). These activities may include chemical synthesis, MCB production, Cell Expansion, Sigilon’s Shielded Living Therapeutics encapsulation, or other Process Development assignments. This role will require daily interaction with stakeholders including but not limited to Regulatory, Quality, Supply Chain, R&D, CMC Analytics, Materials Engineering, etc.). Interpretation
    of scientific data, creation of scientific plans, proposals on process optimization, and technical presentations are expected. This employee will require a strong understanding of scale-up practices and cGMP.
    Hands-on participation internally and with external partners is required.

    Responsibilities

    · Oversee and manage Process Development activities internally and externally.

    · Design and develop processes to optimize efficient process flow,
    reduce process or product variability, improve process capability, and improve process safety.

    · Develop, scale-up, manufacture, and validate products to successful commercialization.

    · Evaluate current processes and provide recommendations.

    · Develop process improvements for high efficiency and cost effectiveness.

    · Provide training and guidance to junior chemists and engineers as needed.

    · Develop and maintain process optimization and validation programs.

    · Research and recommend new technologies to improve efficiency.

    · Participate in process improvement projects to improve product quality, decrease cost, and improve product performance.

    · Communicate technical needs, status, results and observations to technical and business personnel.

    · Ensure that process techniques are in alignment with the corporate goals, quality policies, cGMP, and regulatory requirements.

    · Determine process capability (design space) for all developed processes.

    · Identify and troubleshoot process-related issues.

    Requirements

    • PhD in a relevant engineering, science, or related field is required with minimum 5 years biotech/pharmaceutical cGMP manufacturing experience.
    • Experience with process improvement methodologies (PAT, DOE) is required.
    • Must have prior experience and proficiency in biologics/sterile manufacturing,and a proven track record solving complex technical issues. Experience across the cell therapy supply chain is preferred.
    • Demonstrated technical leadership skills and ability to develop effective scientific processes while maintaining strong relationships with internal/external partners.
    • Understand comprehensive global pharmaceutical cGMP and regulatory requirements.
    • Experience in deviation investigation and CAPA implementation.
    • Strong technical skills.
    • An ability to make technical decisions.
    • Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills.
    • An energetic self-starter who has a track record of productivity and capable of working both independently and as part of multiple collaborative teams.
    • Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs.
    • Travel up to 20%.