Courage to create something that matters

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We are ONE.
We, TOGETHER, are Sigilon.

We care deeply about patients’ and caregivers’ struggles, stories, and triumphs.

We care about rigorous science addressing critical patient needs

We strive to earn and keep the trust of patients, caregivers, and partners.

We respect each other, embrace diversity, and work as one team.

We are passionate about the impact of groundbreaking discoveries.

We dream big and don’t fear failure. We ask “What if we could…?”

We build value for patients and their families, clinicians, partners, and shareholders.

We make sure every experiment and decision counts.

We visualize success and make it happen.

We operate with urgency; patients can’t wait.

Always Growing

We are change-makers, and we never stop in our quest to advance therapies for patients in need. For us that takes a number of forms — we stay abreast of the most recent Sigilon science at our Sigilon Monthly Sessions, where a team member presents their findings and cross-pollination of ideas is encouraged; we also meet up informally, around the weekly Friday breakfast or in our collaboration hubs outside the lab. In this way, we’re always inspiring one another and advancing science that matters.

Never Losing Sight of Our Purpose

We’re at Sigilon to make a difference for patients, and that is front and center in our day to day work. We host patients and caregivers at our offices to learn more about the disease areas we aim to treat. And we stay engaged with the broader community, from organizing a fundraiser to send young people to the New England Hemophilia Association Family Camp, to sponsoring rare disease awareness efforts.

Enjoying Our Relationships

From our Sigilon running team to occasional yoga outings to escape rooms and offsite retreats, we really enjoy our teamwork in all forms. We are a close-knit team with an upbeat atmosphere, and it shows in our productive science — a true team effort.

Life at Sigilon

We have an amazingly collaborative team; we really like each other and this makes working together enjoyable.

Lori

Office Manager/Executive Assistant

I love that we have a fast-paced scientific workplace but where people are so approachable and friendly.

Guillaume

Associate Director, Therapeutic Lead, Hemophilia

My favorite part of the culture at Sigilon is that there’s a balance, which I think is very important in a work environment. There’s a balance between making sure that the employee’s needs are met, but the science is still also a focus and priority.

Rupinderjit

Associate Scientist, Islet Cell Therapy

‘We Together’ is our motto, and there is a reason we selected that. We feel we cannot do anything alone; our science and our functions are so unique that there is no one person that knows everything, but if we put our minds and our hearts and our hands together, we can achieve a lot.

Vanya

Vice President, Head of Human Resources

I think teamwork is very important in the lab because we all are just resources. We can’t know everything, we can’t do everything, so the fact that everyone is there to help you, to contribute to your success, is very important here.

Shaleen

Senior Associate Scientist, Molecular Biology

Everybody’s just nice, smart and interesting to talk to. They’re all about the passion and trying to reach the end goal of helping people, and all of those aspects combined together make Sigilon a great place to work.

Olivia

Vice President, Head of Islet Cell Therapy Research

I think one of the things that’s exciting at Sigilon is that there’s a lot of different components of what we’re trying to do here. There’s always a lot of new learnings and developments that are coming out of the various teams that make up Sigilon.

Ryan

Senior Project Manager, Portfolio

We’ve created an environment here where people are collaborative and friendly, and it makes it enjoyable coming to work every day.

Justin

Senior Project Manager

Current openings

  • Sigilon Therapeutics is seeking an individual with expertise in gene/cell therapy clinical supply, excellent communication skills, and the ability to work in a highly interactive and matrixed environment. The incumbent will oversee day to day patient supply activities for Sigilon clinical trials; including planning and distribution of final products to clinical sites. This role will require daily interaction with stakeholders including but not limited to Clinical Operations, Clinical Research Organizations, Quality, and External Manufacturing. Presentation of
    written and oral summaries of progress in team meetings as well as to management is expected. Supporting the Supply Chain Management on projects as well as leading and participating in supply chain projects as required.

    Responsibilities

    • Lead day to day activities for clinical supply to patients for Sigilon
    • Be point of contact for Clinical Operations and Clinical Research Organizations (CRO) for supply matters (e.g. supply timelines, shipments, etc). Represent Manufacturing and
      Supply Chain on internal clinical study team meetings and CRO meetings
    • Generate and maintain patient demand forecast for ongoing and new programs/studies in coordination with Clinical Operations and New Product Planning
    • Work with Clinical Operations to understand clinical enrollment projections and align coordinate production schedules with External Manufacturing for final product
    • Management shipment of final product from manufacturing sites to clinical study sites. Ensure processes between Sigilon and couriers are functional and efficient
    • Coordinate courier pickups, monitor and track shipments, and resolve any in transit issues
    • Ensure seamless supply activities across shipment, Qualified Person (QP) releases, and site shipment receipt activities with External Manufacturing, Quality, and Clinical Operations
    • Responsible for investigation of transit deviations and CAPA implementation in a timely compliant manner
    • Develop supply strategies to maximize supply efficiency, while identifying risk and developing risk mitigation plans
    • Support External Manufacturing as required on product and material shipment between Contract Manufacturing Organizations (CMO) as required
    • Support in creation and maintenance of Standard Operating Procedures (SOP)
    • Lead projects and process improvements within the Supply Chain
    • Additional responsibilities as required

    Requirements

    • BS in the relevant Business, Chemistry, Biology or related field is required with minimum 6 years biotech/pharmaceutical Supply Chain. MBA/Masters Degree preferred
    • Demonstrates a solid understanding of Supply Chain. Understands interdependencies of parts of supply chain and stakeholders. Uses industry knowledge to drive best-practices within company
    • Demonstrated project leadership skills and ability to develop effective working processes and relationships with internal/external partners and cross-functional project teams
    • Understand comprehensive global pharmaceutical regulatory requirements (e.g. cGMP, GDP, CFRs, Annex 13, ICH E6 (R2), etc)
    • Experience in interacting with Health Authorities (e.g. inspections)
    • Experience in deviation investigation and CAPA implementation
    • Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills
    • An energetic self-starter who is adept at multi-tasking, has a track record of productivity and capable of working both independently and as part of multiple collaborative teams
    • Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs
    • Travel up to 10%