Courage to create something that matters

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We are ONE.
We, TOGETHER, are Sigilon.

We care deeply about patients’ and caregivers’ struggles, stories, and triumphs.

We care about rigorous science addressing critical patient needs

We strive to earn and keep the trust of patients, caregivers, and partners.

We respect each other, embrace diversity, and work as one team.

We are passionate about the impact of groundbreaking discoveries.

We dream big and don’t fear failure. We ask “What if we could…?”

We build value for patients and their families, clinicians, partners, and shareholders.

We make sure every experiment and decision counts.

We visualize success and make it happen.

We operate with urgency; patients can’t wait.

Always Growing

We are change-makers, and we never stop in our quest to advance therapies for patients in need. For us that takes a number of forms — we stay abreast of the most recent Sigilon science at our Sigilon Monthly Sessions, where a team member presents their findings and cross-pollination of ideas is encouraged; we also meet up informally, around the weekly Friday breakfast or in our collaboration hubs outside the lab. In this way, we’re always inspiring one another and advancing science that matters.

Never Losing Sight of Our Purpose

We’re at Sigilon to make a difference for patients, and that is front and center in our day to day work. We host patients and caregivers at our offices to learn more about the disease areas we aim to treat. And we stay engaged with the broader community, from organizing a fundraiser to send young people to the New England Hemophilia Association Family Camp, to sponsoring rare disease awareness efforts.

Enjoying Our Relationships

From our Sigilon running team to occasional yoga outings to escape rooms and offsite retreats, we really enjoy our teamwork in all forms. We are a close-knit team with an upbeat atmosphere, and it shows in our productive science — a true team effort.

Life at Sigilon

My favorite part of the culture at Sigilon is that there’s a balance, which I think is very important in a work environment. There’s a balance between making sure that the employee’s needs are met, but the science is still also a focus and priority.


Associate Scientist, Islet Cell Therapy

‘We Together’ is our motto, and there is a reason we selected that. We feel we cannot do anything alone; our science and our functions are so unique that there is no one person that knows everything, but if we put our minds and our hearts and our hands together, we can achieve a lot.


Vice President, Head of Human Resources

I think teamwork is very important in the lab because we all are just resources. We can’t know everything, we can’t do everything, so the fact that everyone is there to help you, to contribute to your success, is very important here.


Senior Associate Scientist, Molecular Biology

Everybody’s just nice, smart and interesting to talk to. They’re all about the passion and trying to reach the end goal of helping people, and all of those aspects combined together make Sigilon a great place to work.


Vice President, Head of Islet Cell Therapy Research

I think one of the things that’s exciting at Sigilon is that there’s a lot of different components of what we’re trying to do here. There’s always a lot of new learnings and developments that are coming out of the various teams that make up Sigilon.


Senior Project Manager, Portfolio

We’ve created an environment here where people are collaborative and friendly, and it makes it enjoyable coming to work every day.


Senior Project Manager

Current openings

  • Sigilon Therapeutics is looking for an experienced process development scientist to join the team responsible for enhancing and evolving the manufacturing process for Sigilon’s encapsulated allogeneic cell therapy platform. Key objectives will be to develop robust and scalable cell therapy bioprocesses and transfer these processes to contract manufacturing partners.


    • Design and execute process development laboratory studies that support the evaluation, development and implementation of new technologies for cell therapy manufacturing.
    • Perform hands-on lab-based activities in a cell culture lab, including analysis and communication of results to cross-functional teams.
    • Perform process or equipment analysis and trend process or equipment performance.
    • Provide process training to GMP personnel.
    • Support technology transfer and GMP manufacturing operations as needed.
    • Perform statistical analysis including design of experiments (DOEs) as appropriate.
    • Write and review technical documentation, technical SOPs, draft manufacturing batch records, technical reports and summary reports.
    • Support qualification and risk assessment activities for GMP implementation.


    • BS in Biochemical Engineering, Chemical Engineering, Biomedical Engineering, Biotechnology or related discipline with 3+ years biologics manufacturing & process development experience required. Cell therapy specific experience preferred
    • Strong analytical skills to perform statistical analysis as well as proficiency in statistical software (R, JMP, Minitab)
    • Established cell culture lab techniques and aseptic processing in a BSC such as cell passaging, sampling, fluid handling, media formulation, managing reagents, and cryopreservation.
    • Mastery of scientific and engineering principles related to upstream bioprocessing including scale-up / scale-out approaches, hydrodynamics, mass transfer, and bioreactor design and monitoring is desired
    • Practical knowledge of cGMP manufacturing and regulatory regulations and requirements for pharmaceuticals and devices.