Courage to create something that matters

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We are ONE.
We, TOGETHER, are Sigilon.

We care deeply about patients’ and caregivers’ struggles, stories, and triumphs.

We care about rigorous science addressing critical patient needs

Learn how we care

We strive to earn and keep the trust of patients, caregivers, and partners.

We respect each other, embrace diversity, and work as one team.

Learn how we trust

We are passionate about the impact of groundbreaking discoveries.

We dream big and don’t fear failure. We ask “What if we could…?”

Learn how we pioneer

We build value for patients and their families, clinicians, partners, and shareholders.

We make sure every experiment and decision counts.

Learn how we create

We visualize success and make it happen.

We operate with urgency; patients can’t wait.

Learn how we act

Always Growing

We are change-makers, and we never stop in our quest to advance therapies for patients in need. For us that takes a number of forms — we stay abreast of the most recent Sigilon science at our Sigilon Monthly Sessions, where a team member presents their findings and cross-pollination of ideas is encouraged; we also meet up informally, around the weekly Friday breakfast or in our collaboration hubs outside the lab. In this way, we’re always inspiring one another and advancing science that matters.

Never Losing Sight of Our Purpose

We’re at Sigilon to make a difference for patients, and that is front and center in our day to day work. We host patients and caregivers at our offices to learn more about the disease areas we aim to treat. And we stay engaged with the broader community, from organizing a fundraiser to send young people to the New England Hemophilia Association Family Camp, to sponsoring rare disease awareness efforts.

Enjoying Our Relationships

From our Sigilon running team to occasional yoga outings to escape rooms and offsite retreats, we really enjoy our teamwork in all forms. We are a close-knit team with an upbeat atmosphere, and it shows in our productive science — a true team effort.

Life at Sigilon

I love that we have a fast-paced scientific workplace but where people are so approachable and friendly.

Guillaume

Associate Director, Therapeutic Lead, Hemophilia

My favorite part of the culture at Sigilon is that there’s a balance, which I think is very important in a work environment. There’s a balance between making sure that the employee’s needs are met, but the science is still also a focus and priority.

Rupinderjit

Associate Scientist, Islet Cell Therapy

‘We Together’ is our motto, and there is a reason we selected that. We feel we cannot do anything alone; our science and our functions are so unique that there is no one person that knows everything, but if we put our minds and our hearts and our hands together, we can achieve a lot.

Vanya

Vice President, Head of Human Resources

I think teamwork is very important in the lab because we all are just resources. We can’t know everything, we can’t do everything, so the fact that everyone is there to help you, to contribute to your success, is very important here.

Shaleen

Senior Associate Scientist, Molecular Biology

Everybody’s just nice, smart and interesting to talk to. They’re all about the passion and trying to reach the end goal of helping people, and all of those aspects combined together make Sigilon a great place to work.

Olivia

Vice President, Head of Islet Cell Therapy Research

I think one of the things that’s exciting at Sigilon is that there’s a lot of different components of what we’re trying to do here. There’s always a lot of new learnings and developments that are coming out of the various teams that make up Sigilon.

Ryan

Senior Project Manager, Portfolio

We’ve created an environment here where people are collaborative and friendly, and it makes it enjoyable coming to work every day.

Justin

Senior Project Manager

Current openings

Director/Sr. Director, Preclinical Development Program Lead

The employee will lead cross functional teams to drive development programs from research through commercial launch to meet the company’s goals and effectively treat patients. The successful candidate will have a strong knowledge of product development, regulatory requirements, preclinical studies, and manufacturing preferably for cell-based therapy. An ability to think outside of the box and experience with combination products will benefit the candidate for this role. The candidate will also have an excellent execution track record on for on-time delivery, as well as demonstrable strategic insight, creativity for overcoming challenges, and program prioritization skills. This role will require daily interaction with stakeholders in program management, engineering, biology, non-clinical, quality, regulatory, manufacturing, and clinical teams as well as external teams. Presentation of written and oral summaries of progress to senior management and expert consultants will be required.

Responsibilities:
- Lead cross functional team to drive development programs exiting research through to commercial launch
- Lead multi-disciplinary project teams through demonstrating an in-depth knowledge of biologic/combination product development, excellent interpersonal communication skills, leadership skills, and influencing skills
- Ensure transparency throughout development by securing project resources and communicate gaps, identify risks and mitigate/communicate to management, and define critical path items and alert team to changes to critical path items
- Proactively anticipate issues, challenges, and assumptions as well as identify contingencies or creative opportunities to circumvent potential delays
- Guide the team in appropriate decision-making through analyzing options and reviewing implications
- Develop and maintain timelines in partnership with program management for development programs
- Partner with technical leads/SMEs to establish requirements for program success
- Coordinate with nonclinical team for execution of all studies required for regulatory filings
- Work with engineering and encapsulation team to push readiness of product enabling technologies such as packaging, stability, delivery and surgical technique development
- Synchronize with clinical team to ensure readiness of program for trial initiation
- Maintain documentation and write reports to support quality requirements, regulatory filings, IP as needed
Requirements/experience with:
- At least 10 years of relevant industry experience in product development and program management
- MS or PhD preferred; biomedical engineering, biology, program management, or similar field
- Strategic thinker, able to assess the program needs and prioritize according to corporate timelines
- People leadership and mentorship capabilities
- Experience with reparation of FDA submission documents, FDA interactions
- Experience in design, optimization, testing, data analysis and validation protocols
- Outstanding interpersonal skills and established collaborative working habits
- Excellent oral and written communication skills
Apply Now
Sigilon Therapeutics is seeking a Scientist to join the Assays group, which develops and performs biological assays for multiple therapeutic programs across the company.

Responsibilities
- Independently develop and perform standardize protocols for quantifying and assessing the activity of therapeutic proteins, including ELISA / MSD, cell-based assays, and biochemical / enzymatic assays.
- Assess scientific literature in a variety of therapeutic areas to design experiments and develop / optimize assays.
- Analyze, interpret, and present experimental data in multidisciplinary team meetings.
- Write and review SOPs, study reports, posters / publications, and technical sections of regulatory filings.
- Coordinate with molecular / cell biology, engineering, and in vivo team members to ensure timely delivery of assay data.
- Manage projects with external labs and assay transfers.
- Review internally / externally-generated analytical data for accuracy.
- Maintain detailed records in electronic lab notebook and sample management system.
- Evaluate and facilitate adoption of new technology / equipment to expand the capabilities of the Assays group.
Requirements
- Ph.D. in biochemistry, cell biology, molecular biology, or related discipline.
- At least 2 years of experience in the pharmaceutical / biotechnology industry, specifically in developing bioassay protocols.
- Experience with cell and molecular biology techniques, including ELISA / MSD, Western blot, mammalian cell culture, and other gene / protein expression assays.
- Experience with plate-based readers and analysis software, such as SoftMax Pro, BioTek Gen5, GraphPad Prism, and Excel.
- Exceptional attention to detail, particularly as it relates to the accuracy and precision of assays.
- Experience with assay qualification and validation in a GLP environment is a plus.
- Ability to work effectively with minimal supervision after initial training.
- Ability to set priorities and multi-task activities to effectively manage workflows and deliverables.
- Strong team orientation, with excellent written and oral communication skills.
Apply Now
Brigham Young University students ONLY

Intern: Process Engineering

Position Summary:

Sigilon Therapeutics located in Cambridge, MA is searching for an energized and highly motivated candidate to be part of a team focused on
developing a novel therapeutic platform utilizing Sigilon’s Afibromer™ technology to treat a variety of rare diseases.

Sigilon Therapeutics is a biopharmaceutical company creating functional cures for chronic diseases using Shielded Living Therapeutics.
The Shielded Living Therapeutics product platform consists of novel engineered human cells that are encased in a proprietary immune-shielding matrix and placed in the body. These Shielded Living Therapeutics then produce therapeutic proteins in a programmable and durable fashion, without generating fibrosis or immune rejection. Our pipeline of products in hemophilia, lysosomal storage diseases, and, in collaboration with Eli Lilly, type 1 diabetes, are rapidly advancing toward the clinic. Sigilon was founded and created by Flagship Pioneering in conjunction with Daniel Anderson, Ph.D., and Robert Langer, Sc.D., of the Massachusetts Institute of Technology.

This position provides an outstanding training opportunity to work closely with scientists. The Research Assistant will be given their own project or set of tasks and receive close
guidance and mentorship from a Scientist-level supervisor and a Project Manager.

Exemplary Duties and Activities:
- Tissue culture of therapeutic engineered cell lines
- Perform cell-based and molecular biology assays such as cell viability, ELISA, immunohistochemistry, flow cytometry, qPCR, and functional assays
- Make observations, evaluate data, interpret results and maintain good written
  records
- Comply with standard laboratory practices and company policies
Qualifications:
- Preferred basic laboratory skills, including: Experience in tissue culture and cell-based and molecular biology assays, e.g. qPCR, immunohistochemistry, ELISA, and flow cytometry; previous laboratory-based research experience a plus
- Outstanding interpersonal skills and established collaborative working habits
- Excellent oral and written communication skills
Perks:
- T-pass or parking reimbursement (if planning to secure your own garage spot in the
  area) up to $260 per month will be provided.
- Breakfast is provided every other Monday morning.
- Snacks, coffee and soft drinks provided daily.
- Subsidized/ discounted gym membership available at BodyScapes and Cambridge Athletic Club.
What are we looking for?
- An enthusiastic and dedicated student that is interested in regenerative medicine and creating novel treatments
- Laboratory skills in molecular biology, cell biology or related sciences are preferred
- Leading the way: A creative and dedicated scientist
- Working together: A colleague to thrive on collaboration with our scientific teammates
- Loving what you do: A team member with positive energy that is passionate about our mission
What are we offering?

· Exposure to pioneering science and the opportunity to help create therapeutics that will benefit patients with rare, chronic conditions

· Unique opportunity to develop skills and deliver important experimental results at a
small company

· Manager & co-workers who are proven mentors and coaches

· Membership within a growing, dynamic and collegial organization

Process Engineering Intern

An Intern student in the Process Engineering group would have the opportunity to learn cell and molecular biology techniques for a variety of cell types, including mammalian and stem cell culture, qPCR, flow cytometry, ELISA, and others. The candidate will be an integral member of a small research team and will receive close guidance and mentorship from a senior scientist level supervisor and a project manager. The individual will be given their own project and set of tasks within a project and be an integral contributor. Projects will be designed based on (1) the current progress and challenges to the research program, and (2) the capabilities of the individual.
Apply Now
Sigilon Therapeutics is seeking an individual with expertise in pharmaceutical/biotechnology quality assurance, excellent communication skills, and the ability to work in a highly interactive and matrixed environment. The incumbent will serve as integral member of the Quality Group, focusing on implementation, maintenance and oversight of QMS documentation, administration of the corporate training program, deviation and CAPA management, and internal auditing, This role will require daily interaction with stakeholders including but not limited to Chemistry, Biology, Clinical Operations, Contract Manufacturing Organizations (CMOs), Clinical Research Organizations (CROs), and External Testing Laboratories.

Presentation of written and oral summaries of progress in team meetings as well as to management is expected. Supporting Quality initiatives as well as leading and participating in Quality projects as required.

Responsibilities:
- Quality Management System (QMS) Documentation Oversight and Compliance
- Manage implementation, management, and maintenance for all QMS procedural documents for all operational departments and acquisitions including archive and electronic storage of original signature documents
- Initiate and drive to completion the review/revision of all QMS documents per plans and schedules
- Assume primary authorship or major contributor for specific procedural revisions as assigned
- Batch record and C of A review and release
- Administration of corporate training program (in collaboration with department heads) involves the following activities:
- In collaboration with department heads, monitor global compliance to Corporate Training Policy and implement needed corrective and preventive actions
- Maintain role-based definitions of training requirements, enroll staff in computer-based-training programs, track staff training compliance to completion
- Report and escalate training non-compliance to senior management as applicable
- Support audit requests for training records including review of training and ad hoc corrections to those requested records as necessary.
- Internal Audits
- Prepare, conduct, and produce reports for process audits of key Sigilon departments and workflows on a scheduled basis to confirm compliance with the established SOPs
- Such audits include but are not limited to Chemistry, Biology, Engineering, IT, Manufacturing. Ensure all findings are resolved effectively in a timely manner.
- External Audits
- Prepare, conduct, and produce reports for process audits of key Sigilon suppliers/vendors on a scheduled basis to confirm compliance to relevant global regulatory regulations,master and quality agreements
- Such audits include but are not limited to CROs, CMOs and External Testing Laboratories
- Ensure all findings are resolved effectively in a timely manner.
Requirements
- B.S./B.A. Degree in scientific discipline, with a minimum 3 years of previous experience in quality assurance and systems in an FDA regulated or similar environment preferred.
- Experience with electronic document management systems, quality management systems, and electronic learning management systems (LMS). Working knowledge of relevant industry and government regulations including: 21 CFR 11. cGMP, GDP, CFRs, Annex 13, ICH E6 (R2). Uses industry knowledge to drive best-practices within company
- Demonstrated project leadership skills and ability to develop effective working processes and relationships with internal/external partners and cross-functional project teams
- Understand comprehensive global pharmaceutical regulatory requirements (e.g. cGMP, GDP, CFRs, Annex 13, ICH E6 (R2), etc)
- Experience in interacting with Health and Regulatory Authorities (e.g. inspections)
- Experience in deviation investigation and CAPA implementation
- Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills
- An energetic self-starter who is adept at multi-tasking, has a track record of productivity and capable of working both independently and as part of multiple collaborative teams
- Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs
- Travel up to 10%
Special considerations:
- Candidate must possess effective communication skills, and proven abilities in interfacing with colleagues in a number of different departments and managing multiple projects/priorities. Must be methodical, well organized and detail oriented. Individual must be highly self-motivated, readily adaptable to a fast-paced, multidisciplinary team-based environment and capable of working autonomously with little direct supervision.
Apply Now
Sigilon Therapeutics is searching for an energized and highly motivated Scientist to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. The candidate should have experience with development of a cell therapy or a biologic product.

Responsibilities
- Oversee production and evaluation of therapeutic cells for preclinical studies
- Establishing SOPs for processes and assays for technology transfer to CMOs and CROs
- Design of study protocols, coordination of study execution, and writing and review of study reports for non-GLP and GLP nonclinical studies performed in house and at external CROs
- Writing and review of regulatory submissions
- Demonstrate understanding and application of relevant scientific literature to the design of experimental protocols
- Adept at organization and analysis of data sets for tracking and trending and statistical analyses
- Present results of experiments and findings in multidisciplinary team meetings
- Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects
- Comply with standard laboratory practices and company policies
Requirements
- Ph.D. in the biological sciences with minimum 10 years biotech/pharmaceutical experience developing a product
- Must have prior experience and proficiency with technical writing including SOPs, study protocols and reports, IACUC protocols, and regulatory submissions
- Knowledge of GMP and GLP guidelines
- Skills in MS Office (Word, PowerPoint, Excel, Outlook) and data analysis
- Ability to work and succeed within a matrixed organization
- Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills.
- Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs.
- Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
Apply Now
Sigilon Therapeutics is seeking an individual with expertise in gene/cell therapy clinical supply, excellent communication skills, and the ability to work in a highly interactive and matrixed environment. The incumbent will oversee day to day patient supply activities for Sigilon clinical trials; including planning and distribution of final products to clinical sites. This role will require daily interaction with stakeholders including but not limited to Clinical Operations, Clinical Research Organizations, Quality, and External Manufacturing. Presentation of
written and oral summaries of progress in team meetings as well as to management is expected. Supporting the Supply Chain Management on projects as well as leading and participating in supply chain projects as required.

Responsibilities
- Lead day to day activities for clinical supply to patients for Sigilon
- Be point of contact for Clinical Operations and Clinical Research Organizations (CRO) for supply matters (e.g. supply timelines, shipments, etc). Represent Manufacturing and
  Supply Chain on internal clinical study team meetings and CRO meetings
- Generate and maintain patient demand forecast for ongoing and new programs/studies in coordination with Clinical Operations and New Product Planning
- Work with Clinical Operations to understand clinical enrollment projections and align coordinate production schedules with External Manufacturing for final product
- Management shipment of final product from manufacturing sites to clinical study sites. Ensure processes between Sigilon and couriers are functional and efficient
- Coordinate courier pickups, monitor and track shipments, and resolve any in transit issues
- Ensure seamless supply activities across shipment, Qualified Person (QP) releases, and site shipment receipt activities with External Manufacturing, Quality, and Clinical Operations
- Responsible for investigation of transit deviations and CAPA implementation in a timely compliant manner
- Develop supply strategies to maximize supply efficiency, while identifying risk and developing risk mitigation plans
- Support External Manufacturing as required on product and material shipment between Contract Manufacturing Organizations (CMO) as required
- Support in creation and maintenance of Standard Operating Procedures (SOP)
- Lead projects and process improvements within the Supply Chain
- Additional responsibilities as required
Requirements
- BS in the relevant Business, Chemistry, Biology or related field is required with minimum 6 years biotech/pharmaceutical Supply Chain. MBA/Masters Degree preferred
- Demonstrates a solid understanding of Supply Chain. Understands interdependencies of parts of supply chain and stakeholders. Uses industry knowledge to drive best-practices within company
- Demonstrated project leadership skills and ability to develop effective working processes and relationships with internal/external partners and cross-functional project teams
- Understand comprehensive global pharmaceutical regulatory requirements (e.g. cGMP, GDP, CFRs, Annex 13, ICH E6 (R2), etc)
- Experience in interacting with Health Authorities (e.g. inspections)
- Experience in deviation investigation and CAPA implementation
- Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills
- An energetic self-starter who is adept at multi-tasking, has a track record of productivity and capable of working both independently and as part of multiple collaborative teams
- Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs
- Travel up to 10%
Apply Now
We are look for a motivated immunologist with a passion for innovation to develop novel technologies to optimize and regulate production of therapeutic proteins in vivo.

Responsibilities

· Spearhead and lead internal research projects to investigate immune mechanisms and novel disease applications of our cell therapy platform

· Present results of experiments and findings in multidisciplinary team meetings

· Conceive, design and implement novel cell-engineering technologies to regulate production of therapeutic proteins.

· Manage external projects with CROs and external collaborators.

· Work in a fast moving, highly interactive matrixed dynamic business environment and changing project portfolios

Requirements

· Ph.D. degree in Immunology

· Previous Industry experience would be a plus.

· Management experience desirable.

· Experience in tissue culture, cell-based assays and flow cytometry and other standard immunological assays.

· Outstanding interpersonal skills and established collaborative working habits.

· Excellent oral and written communication skills

· Must enjoy coming to work and having fun while creating therapies that improve the lives of patients

Apply Now