Courage to create something that matters

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We are ONE.
We, TOGETHER, are Sigilon.

We care deeply about patients’ and caregivers’ struggles, stories, and triumphs.

We care about rigorous science addressing critical patient needs

Learn how we care

We strive to earn and keep the trust of patients, caregivers, and partners.

We respect each other, embrace diversity, and work as one team.

Learn how we trust

We are passionate about the impact of groundbreaking discoveries.

We dream big and don’t fear failure. We ask “What if we could…?”

Learn how we pioneer

We build value for patients and their families, clinicians, partners, and shareholders.

We make sure every experiment and decision counts.

Learn how we create

We visualize success and make it happen.

We operate with urgency; patients can’t wait.

Learn how we act

Always Growing

We are change-makers, and we never stop in our quest to advance therapies for patients in need. For us that takes a number of forms — we stay abreast of the most recent Sigilon science at our Sigilon Monthly Sessions, where a team member presents their findings and cross-pollination of ideas is encouraged; we also meet up informally, around the weekly Friday breakfast or in our collaboration hubs outside the lab. In this way, we’re always inspiring one another and advancing science that matters.

Never Losing Sight of Our Purpose

We’re at Sigilon to make a difference for patients, and that is front and center in our day to day work. We host patients and caregivers at our offices to learn more about the disease areas we aim to treat. And we stay engaged with the broader community, from organizing a fundraiser to send young people to the New England Hemophilia Association Family Camp, to sponsoring rare disease awareness efforts.

Enjoying Our Relationships

From our Sigilon running team to occasional yoga outings to escape rooms and offsite retreats, we really enjoy our teamwork in all forms. We are a close-knit team with an upbeat atmosphere, and it shows in our productive science — a true team effort.

Life at Sigilon

We have an amazingly collaborative team; we really like each other and this makes working together enjoyable.

Lori

Office Manager/Executive Assistant

I love that we have a fast-paced scientific workplace but where people are so approachable and friendly.

Guillaume

Associate Director, Therapeutic Lead, Hemophilia

My favorite part of the culture at Sigilon is that there’s a balance, which I think is very important in a work environment. There’s a balance between making sure that the employee’s needs are met, but the science is still also a focus and priority.

Rupinderjit

Associate Scientist, Islet Cell Therapy

‘We Together’ is our motto, and there is a reason we selected that. We feel we cannot do anything alone; our science and our functions are so unique that there is no one person that knows everything, but if we put our minds and our hearts and our hands together, we can achieve a lot.

Vanya

Vice President, Head of Human Resources

I think teamwork is very important in the lab because we all are just resources. We can’t know everything, we can’t do everything, so the fact that everyone is there to help you, to contribute to your success, is very important here.

Shaleen

Senior Associate Scientist, Molecular Biology

Everybody’s just nice, smart and interesting to talk to. They’re all about the passion and trying to reach the end goal of helping people, and all of those aspects combined together make Sigilon a great place to work.

Olivia

Vice President, Head of Islet Cell Therapy Research

I think one of the things that’s exciting at Sigilon is that there’s a lot of different components of what we’re trying to do here. There’s always a lot of new learnings and developments that are coming out of the various teams that make up Sigilon.

Ryan

Senior Project Manager, Portfolio

We’ve created an environment here where people are collaborative and friendly, and it makes it enjoyable coming to work every day.

Justin

Senior Project Manager

Current openings

Sigilon Therapeutics is seeking an individual with expertise in gene/cell therapy clinical supply, excellent communication skills, and the ability to work in a highly interactive and matrixed environment. The incumbent will oversee day to day patient supply activities for Sigilon clinical trials; including planning and distribution of final products to clinical sites. This role will require daily interaction with stakeholders including but not limited to Clinical Operations, Clinical Research Organizations, Quality, and External Manufacturing. Presentation of
written and oral summaries of progress in team meetings as well as to management is expected. Supporting the Supply Chain Management on projects as well as leading and participating in supply chain projects as required.

Responsibilities
- Lead day to day activities for clinical supply to patients for Sigilon
- Be point of contact for Clinical Operations and Clinical Research Organizations (CRO) for supply matters (e.g. supply timelines, shipments, etc). Represent Manufacturing and
  Supply Chain on internal clinical study team meetings and CRO meetings
- Generate and maintain patient demand forecast for ongoing and new programs/studies in coordination with Clinical Operations and New Product Planning
- Work with Clinical Operations to understand clinical enrollment projections and align coordinate production schedules with External Manufacturing for final product
- Management shipment of final product from manufacturing sites to clinical study sites. Ensure processes between Sigilon and couriers are functional and efficient
- Coordinate courier pickups, monitor and track shipments, and resolve any in transit issues
- Ensure seamless supply activities across shipment, Qualified Person (QP) releases, and site shipment receipt activities with External Manufacturing, Quality, and Clinical Operations
- Responsible for investigation of transit deviations and CAPA implementation in a timely compliant manner
- Develop supply strategies to maximize supply efficiency, while identifying risk and developing risk mitigation plans
- Support External Manufacturing as required on product and material shipment between Contract Manufacturing Organizations (CMO) as required
- Support in creation and maintenance of Standard Operating Procedures (SOP)
- Lead projects and process improvements within the Supply Chain
- Additional responsibilities as required
Requirements
- BS in the relevant Business, Chemistry, Biology or related field is required with minimum 6 years biotech/pharmaceutical Supply Chain. MBA/Masters Degree preferred
- Demonstrates a solid understanding of Supply Chain. Understands interdependencies of parts of supply chain and stakeholders. Uses industry knowledge to drive best-practices within company
- Demonstrated project leadership skills and ability to develop effective working processes and relationships with internal/external partners and cross-functional project teams
- Understand comprehensive global pharmaceutical regulatory requirements (e.g. cGMP, GDP, CFRs, Annex 13, ICH E6 (R2), etc)
- Experience in interacting with Health Authorities (e.g. inspections)
- Experience in deviation investigation and CAPA implementation
- Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills
- An energetic self-starter who is adept at multi-tasking, has a track record of productivity and capable of working both independently and as part of multiple collaborative teams
- Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs
- Travel up to 10%
Apply Now
Scientist, Islet Cell Therapy

Sigilon Therapeutics is searching for an energized and highly motivated Scientist to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. The candidate should have experience with diabetes, stem cell biology, or cell therapies.

Responsibilities

· Tissue culture of primary cells and cell lines
- Establishing protocols and SOPs
- Design, perform and interpret data from cell-based assays and molecular biology assays
· Demonstrate understanding and application of relevant scientific literature to the design of experimental protocols

· Adept at organization and analysis of large data sets for tracking and trending and statistical analyses

· Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook

· Present results of experiments and findings in multidisciplinary team meetings

· Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects

· Comply with standard laboratory practices and company policies

Requirements
- Ph.D. degree in the biological sciences
- Experience in industry or academia investigating with diabetes, stem cell biology, or cell therapies
- Experience in writing SOPs
- Experience with jmp or comparable analysis software
- Outstanding interpersonal skills and established collaborative working habits
- Experience with analytical development is a plus
- Excellent oral and written communication skills
- Skills in MS Office: Word, PowerPoint, Excel, Outlook
- Ability to work and succeed within a matrixed organization
- Demonstrated success in scientific prowess as demonstrated by publications
- Must enjoy coming to work and having fun while creating therapies that improve the lives of patients
Apply Now
Sigilon Therapeutics is seeking an individual with broad expertise in pharmaceutical Process Development, excellent communication skills, and the ability to work in a highly interactive and matrixed environment. The incumbent will oversee the aspects of scientific Process Development activities conducted internally and at Contract Manufacturing Organizations (CMOs). These activities may include chemical synthesis, MCB production, Cell Expansion, Sigilon’s Shielded Living Therapeutics™ encapsulation, or other Process Development assignments. This role will require daily interaction with stakeholders including but not limited to Regulatory, Quality, Supply Chain, R&D, CMC Analytics, Materials Engineering, etc.). Interpretation
of scientific data, creation of scientific plans, proposals on process optimization, and technical presentations are expected. This employee will require a strong understanding of scale-up practices and cGMP. Hands-on participation internally and with external partners is required.

Responsibilities

· Oversee and manage Process Development activities internally and externally.

· Design and develop processes to optimize efficient process flow,
reduce process or product variability, improve process capability, and improve process safety.

· Develop, scale-up, manufacture, and validate products to successful commercialization.

· Evaluate current processes and provide recommendations.

· Develop process improvements for high efficiency and cost effectiveness.

· Provide training and guidance to junior chemists and engineers as needed.

· Develop and maintain process optimization and validation programs.

· Research and recommend new technologies to improve efficiency.

· Participate in process improvement projects to improve product quality, decrease cost, and improve product performance.

· Communicate technical needs, status, results and observations to technical and business personnel.

· Ensure that process techniques are in alignment with the corporate goals, quality policies, cGMP, and regulatory requirements.

· Determine process capability (design space) for all developed processes.

· Identify and troubleshoot process-related issues.

Requirements

PhD in a relevant engineering, science, or related field is required with minimum 5 years biotech/pharmaceutical cGMP manufacturing experience.

Experience with process improvement methodologies (PAT, DOE) is required.

Must have prior experience and proficiency in biologics/sterile manufacturing,and a proven track record solving complex technical issues. Experience across the cell therapy supply chain is preferred.

Demonstrated technical leadership skills and ability to develop effective scientific processes while maintaining strong relationships with internal/external partners.

Understand comprehensive global pharmaceutical cGMP and regulatory requirements.

Experience in deviation investigation and CAPA implementation.

Strong technical skills.

An ability to make technical decisions.

Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills.

An energetic self-starter who has a track record of productivity and capable of working both independently and as part of multiple collaborative teams.

Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs.

Travel up to 20%.
Apply Now
The Scientist/Sr. Scientist position is responsible for new method development and characterization of Sigilon’s cell therapy drug product to support release, stability and compatibility testing in CMC Analytics. The job function is described as follows -

Responsibilities
- Design and develop new methods to support characterization
  and comparability of biomolecules and encapsulated cell therapy.
- Conduct experiment to characterize capsular surface and
  correlate the physicochemical parameters with structural and functional readouts
  to support manufacturing and comparability studies.
- Manage and monitor progress of external projects with CROs
  and collaborators; understand and interpret data and present the results with in-depth
  analytical thinking.
- Support routine sample testing and schedules within CMC
  Analytics.
- Perform troubleshooting of assays to support assay
  qualification, optimization and continuous improvement.
- Represent CMC Analytics in multidisciplinary team to support
  product development and CMC.
- Work in a fast moving, highly interactive and matrixed
  dynamic environment.
Requirements
- Ph.D. degree in Analytical Chemistry or Biophysics
- Minimum of 2 years industry experience required.
- Experience with modern spectroscopy and imaging techniques including,
  but not limited to, mass spectrometry, MALDI-TOF imaging, TOF-SIMS, atomic
  force microscopy, confocal Raman mapping, confocal laser scanning microscopy, electron
  microscopy, light scattering, time-resolved spectroscopy, X-ray photoelectron
  spectroscopy.
- Experience in conjugation chemistry and encapsulation.
- Experience in HPLC.
- Outstanding interpersonal skills and collaborative working
  habits.
- Excellent oral and written communication skills.
- Must enjoy coming to work and having fun while creating breakthrough
  therapies that improve the lives of patients.
Apply Now
Sigilon Therapeutics is searching for an energized and highly motivated candidate assistant/associate scientist to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. The candidate should have experience with cell/molecular biology and in vivo studies.

Responsibilities

· Conduct hands-on in vivo studies in rodents which requires drug administration, blood and tissue collection

· Make observations, collect and analyze data, maintain records, interpret results, prepare documents, and keep a well-maintained laboratory notebook

· Establishing protocols and SOPs

· Perform in vitro assays including cell viability, ELISA, immunohistochemistry, and various functional assays

· Aseptic tissue culture of cells

· Demonstrate understanding and application of relevant scientific literature to experimental design

· Present results of experiments and findings in multidisciplinary team meetings

· Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects

· Comply with standard laboratory practices and company policies

Requirements

· Sc. or M.Sc. degree with a focus on biology, cell/molecular biology, or physiology

· Minimum of 2 years laboratory experience in industry or academia desirable

· Experience in rodent handling, blood collection, tissue harvesting and processing of biological samples

· Experience in cell culture and/or molecular biology assays

· Outstanding interpersonal skills and established collaborative working habits

· Excellent oral and written communication skills

· Must enjoy coming to work and having fun while creating therapies that improve the lives of patients

Apply Now
Sigilon Therapeutics is searching for an energized and highly motivated candidate assistant/associate scientist to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. The candidate should have experience with cell and molecular biology, liquid handling applications or microfluidics, and automation of data analysis.

Responsibilities

· Aseptic tissue culture of cells

· Automation of data analysis to enable high-throughput experimental design

· Establishing protocols and SOPs

· Perform in vitro assays including cell viability, ELISA, immunohistochemistry, and various functional assays

· Demonstrate understanding and application of relevant scientific literature experimental design

· Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook

· Present results of experiments and findings in multidisciplinary team meetings

· Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects

· Comply with standard laboratory practices and company policies

Requirements

· Sc. or M.Sc. degree with a focus on biology, cell/molecular biology, or bioengineering

· Minimum of 2 years laboratory experience in industry or academia desirable

· Experience in cell culture and/or molecular biology assays

· Experience in liquid handling / assay automation or microfluidics

· Knowledge of basic programming languages (e.g. MATLAB, Python, R, etc) desirable

· Outstanding interpersonal skills and established collaborative working habits

· Excellent oral and written communication skills

· Must enjoy coming to work and having fun while creating therapies that improve the lives of patients

Apply Now
Cell Biology / Cell Culture Intern

The intern will be responsible for performing cell engineering and biological assays. The successful candidate will also assist in the development and characterization of novel engineered cell lines. This role will require daily interaction with stake holders in engineering, biology, in vivo, regulatory, and clinical teams. Presentation of written and oral summaries of progress in team meetings as well as to management is expected. This employee will operate a diverse array of development, manufacturing, and analytical equipment and maintain a safe laboratory environment.

Responsibilities:
- Molecular and cell biology techniques, including ELISA, western blot and PCR
- Stable transfection and selection of engineered cell lines
- Work in a matrixed environment to ensure engineered cell lines meet the needs of the in vivo team
- Assess data, develop logical next steps, and present to science leadership
- Participate in in the coordination of assigned research with other teams as necessary to ensure
  the completion of the team’s research projects
Requirements/experience with:
- Currently pursing PhD in cell biology or closely related field
- Experience in tissue culture, cell-based assays, qPCR, western-blotting and ELISA
- Outstanding interpersonal skills and established collaborative working
  habits
- Excellent oral and written communication skills
- Must be available to start work in the immediate future
- Must have authorization to work in the United States
Apply Now
Sigilon Therapeutics is seeking an individual with broad expertise in external manufacturing, excellent communication skills, and the ability to work in a highly interactive and matrixed environment. The incumbent will oversee Contract Manufacturing Organizations (CMOs) for MCB, Cell Expansion, and Sigilon’s Shielded Living Therapeutics™ encapsulation, and labeling; including managing the business relationship, negotiating contracts, ensuring the successful CMO supply of product, and achieving operational and business goals. The successful candidate will also assist in managing distribution between CMOs. This role will require daily interaction with stakeholders including but not limited to Regulatory, Quality, TechOps (Manufacturing, Supply Chain, Process Chemistry, Device & Delivery Engineering, CMC Analytics, Materials Engineering, etc). Presentation of written and oral summaries of progress in team meetings as well as to management is expected. This employee will operate a diverse array of development, manufacturing, and analytical equipment and maintain a safe laboratory environment.

Responsibilities
- Oversee and manage the relationship of CMOs for MCB, Cell Expansion, and Sigilon’s Shielded Living Therapeutics™ encapsulation, and labeling; including but not limited to:
Participates and contributes in CMO selections and evaluates a CMO’s capacity and capability as an input to a sourcing decision. Supports Quality and TechOps on vendor qualification activities

Managing contract setup, negotiation, and maintenance (in collaboration with TechOps, Quality, and Legal)

Manage budget and ongoing spend for contracted activities

Establish and lead Quarterly Business Reviews and monitor and report performance according to KPIs

Facilitate regular project meetings with CMOs and internal stakeholders (TechOps, Quality, Project Management)

Managing and solving potential disagreements, contract breaches etc. (in collaboration with TechOps, Quality, and Legal)

Ensure processes between Sigilon and CMOs are functional and efficient
- Create and oversee CMO level supply plans and production schedules (e.g. capacity, forecast, material inventory) to deliver timely product. Identifies supply constraints and leads timely resolution of issues. Monitor schedule adherence of product schedules and make course corrections if needed
- Ensure effective communication and coordination between CMOs and stakeholders (e.g. TechOps, Quality, Project Management) so that product/project needs for tech transfer, cGMP manufacturing, and decommissioning are defined and met
- Support the investigation of exceptions and determine root causes, implement CAPAs and drive to closure. Follow-up of change control ton ensure timely implementation in line with regulatory and stock management constraints
- Oversee labeling activities at CMOs and ensure labels are in compliance to regulations
- Coordinate product and material shipment between CMOs. Acts as backup for shipments from CMO to clinical sites
- Ensure Product Security requirements at CMOs are implemented and maintained
- Develop supply strategies to maximize supply efficiency, while identifying risk and developing risk mitigation plans
- Lead cross functional projects and process improvements related to Supply Chain
- Assist in the creation and maintenance of Standard Operating Procedures
- Additional responsibilities as required
Requirements
- BS in the relevant Engineering, Science, or related field is required with minimum 6 years biotech/pharmaceutical cGMP manufacturing experience. An advanced degree (MBA, MS, or PhD) is preferred
- Certification in Project Management (e.g. PMI certification) and process improvement methodologies (e.g. Six Sigma) is a plus
- Must have prior experience and proficiency in biologics/sterile manufacturing, and a proven track record solving complex technical issues. Experience across the cell therapy supply chain preferred
- Demonstrated project leadership skills and ability to develop effective working processes and relationships with internal/external partners and cross-functional project teams
- Understand comprehensive global pharmaceutical regulatory requirements (e.g. cGMP, GDP, CFRs, Annex 13, etc). Knowledge of product security programs
- Experience in interacting with Health Authorities (e.g. inspections)
- Experience in deviation investigation and CAPA implementation
- Strong negotiation skills
- Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills
- An energetic self-starter who is adept at multi-tasking, has a track record of productivity and capable of working both independently and as part of multiple collaborative teams
- Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs
- Travel up to 50%
Apply Now
We are look for a motivated immunologist with a passion for innovation to develop novel technologies to optimize and regulate production of therapeutic proteins in vivo.

Responsibilities

· Spearhead and lead internal research projects to investigate immune mechanisms and novel disease applications of our cell therapy platform

· Present results of experiments and findings in multidisciplinary team meetings

· Conceive, design and implement novel cell-engineering technologies to regulate production of therapeutic proteins.

· Manage external projects with CROs and external collaborators.

· Work in a fast moving, highly interactive matrixed dynamic business environment and changing project portfolios

Requirements

· Ph.D. degree in Immunology

· Previous Industry experience would be a plus.

· Management experience desirable.

· Experience in tissue culture, cell-based assays and flow cytometry and other standard immunological assays.

· Outstanding interpersonal skills and established collaborative working habits.

· Excellent oral and written communication skills

· Must enjoy coming to work and having fun while creating therapies that improve the lives of patients

Apply Now
Sigilon Therapeutics is seeking an individual with broad expertise in in-vivo and translational biology, excellent communication
skills, and the ability to work in a highly interactive and matrixed environment.

Responsibilities:

• The position is a 70% hands-on, laboratory-based role.

• Demonstrate understanding and application of relevant scientific literature to the design of experimental protocols, work with therapeutic leads to develop disease or surgical models

• Establish study protocols, IACUC protocols, internal SOP

• Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook, authoring study reports

• Present results of experiments and findings in multidisciplinary team meetings

• Coordinate in vivo research with other teams as necessary to ensure the completion of the team’s research projects

• Conduct and coordinate in vivo research in external academic collaborations and an extensive network of CROs

• Conduct hands-on in-vivo studies in rodents which requires surgical implantation, dosing, necropsy, blood and tissue collection

• Comply with standard laboratory practices and company policies

Requirements:

• Ph. D in biological sciences or M.Sc. with a minimum of 5 years industry experience.

• Experience working with CROs to carry out pharmacology, toxicology and PK/PD studies

• Must have prior experience and proficiency in drug substance administration, blood collection, tissue harvesting and processing of biological samples

• Experience with rodent and large animal surgery is a plus

• Possess a strong attention to detail and have exceptional interpersonal, organizational and communication skills

• An energetic self-starter who is adept at multi-tasking, has a track record of productivity and capable of working both independently and as part of multiple collaborative teams

• Ability to prioritize responsibilities to meet project deadlines and flexibility to react quickly to changing research needs

Apply Now