Vice President, Clinical Operations

Sigilon Therapeutics is a biopharmaceutical company creating functional cures for chronic diseases using Shielded Living Therapeutics. The Shielded Living Therapeutics product platform consists of novel engineered human cells that are encased in a proprietary immune-shielding matrix and placed in the body. These Shielded Living Therapeutics then produce therapeutic proteins in a programmable and durable fashion, without generating fibrosis or immune rejection. Our pipeline of products in hemophilia, lysosomal storage diseases, and, in collaboration with Eli Lilly, type 1 diabetes, are rapidly advancing toward the clinic. Sigilon was founded and created by Flagship Pioneering in conjunction with Daniel Anderson, Ph.D., and Robert Langer, Sc.D., of the Massachusetts Institute of Technology. Please forward your application via email to

The Head of Clinical Operations is responsible for providing operational leadership for the successful initiation of clinical stage programs at Sigilon Therapeutics. The incumbent ensures that clinical stage projects achieve program objectives within established cost and timelines and provides direction and management oversight to external partners and vendors. This is an exciting opportunity to step into a newly created role reporting directly into Sigilon’s Chief Medical Officer (CMO).