We are seeking versatile scientists to help us create immune privileged products that address unmet clinical needs.

Culture

  • We look for employees who are intellectually curious, willing to ask questions and take measured risks. When an employee joins Sigilon Therapeutics, they become part of the Sigilon Therapeutics family.

  • The ability for prospective employees to fit within the Sigilon Therapeutics culture is a critical consideration.

Sigilon Therapeutics is a biopharmaceutical company creating functional cures for chronic diseases using Shielded Living Therapeutics. The Shielded Living Therapeutics product platform consists of novel engineered human cells that are encased in a proprietary immune-shielding matrix and placed in the body. These Shielded Living Therapeutics then produce therapeutic proteins in a programmable and durable fashion, without generating fibrosis or immune rejection. Our pipeline of products in hemophilia, lysosomal storage diseases, and, in collaboration with Eli Lilly, type 1 diabetes, are rapidly advancing toward the clinic. Sigilon was founded and created by Flagship Pioneering in conjunction with Daniel Anderson, Ph.D., and Robert Langer, Sc.D., of the Massachusetts Institute of Technology.

Please forward your application via email to careers@sigilon.com

    Current Openings

  • Assistant / Associate Scientist, Islet Cell Therapy

    Sigilon Therapeutics is searching for an energized and highly motivated candidate assistant/associate scientist to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. The candidate should have experience with tissue culture of cell lines and with cell and molecular biology assays.

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  • Assistant Scientist/Associate Scientist, Biomaterials

    Assistant Scientist/Associate Scientist- Biomaterials with tissue culture experience of primary cells and cell line, encapsulation of cells in novel biopolymer systems, maintenance and setting up of encapsulation systems.

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  • Assistant Scientist/Associate Scientist, Cell Biology

    The ideal candidate will transition easily into the tissue culture of primary cells and cell lines as well as the stable transfection and selection of engineered cell lines and more.

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  • Director of CMC, Analytics

    Sigilon Therapeutics is searching for an energized candidate to execute our analytical CMC strategy. The new Director of CMC Analytics will collaborate with R&D to develop, qualify and tech transfer assays to CMO/CRO partners as our lead programs advance into clinical development in 2019. Overall goals are to manage the life cycle of assay development and specifications during CMC development, including providing technical guidance and documentation for CMO/CRO partners. This position will be responsible for development, qualification and support of non-GMP and GMP in process and release testing for both drug substance and drug product and will work closely with other CMC functional areas, R&D, Quality, and outside contractors.

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  • Principal / Senior Associate Scientist, Assays

    Sigilon Therapeutics is seeking an experienced  Senior Associate Scientist to join a new team that develops and delivers biological assays for multiple therapeutic programs across the company.

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  • Scientist, Islet Cell Therapy

    Sigilon Therapeutics is searching for an energized and highly motivated Scientist to be part of a team focused on developing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology. The candidate should have experience with diabetes and pancreatic islet biology, including functional analyses of islets in vitro and in vivo.

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  • Scientist, Process Development

     

    As our lead programs advance into clinical development in 2019, Sigilon is looking for experienced process development scientists to join the team responsible for enhancing and evolving the manufacturing process for Sigilon’s encapsulated allogeneic cell therapy platform. Key objectives will be to develop robust and scalable cell therapy bioprocesses and transfer these processes to contract manufacturing partners.

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  • Senior Director - Therapeutic Area Lead

    Seeking Directors for Immunology, Metabolic Diseases and Neurology

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  • Senior Director / Director, Medical Affairs

    Reporting to the Chief Medical Officer, the Head of Medical Affairs is located in the US headquarters for Sigilon Therapeutics in Cambridge, MA and is responsible for facilitating the cross functional coordination of publication strategy, scientific communications, congress planning, medical information and scientific boards across various therapeutic areas of relevance to Sigilon’s scientific platform.

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  • Senior Director CMC, Islet Cell Therapy

    Sigilon Therapeutics is searching for an energized candidate to lead a new team focused on CMC and manufacturing a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge pancreatic islet cell technology.

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  • Senior Director, External Manufacturing

    Sigilon Therapeutics is searching for an energized candidate to manage external strategic partners. Responsible for the relationships with partners that provide process development and cGMP manufacturing services for small molecule chemical synthesis, polymer chemistry and cell therapy biologics manufacturing.

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  • Senior Mechanical Engineer

    The incumbent will be responsible for developing and performing methods to characterize laparoscopic delivery devices and equipment. The successful candidate will also assist in the development of methods to characterize hydrogel-based tissue scaffolds. This role will require daily interaction with stake holders in engineering, biology, and surgery. Presentation of written and oral summaries of progress in team meetings, as well as to management is expected. This employee will operate a diverse array of analytical equipment and maintain a safe laboratory environment

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  • Senior Process Engineer

    As our lead programs advance into clinical development in 2019, Sigilon is looking for an experienced process development scientist to lead the team responsible for enhancing and evolving the manufacturing process for Sigilon’s encapsulated allogeneic cell therapy platform. Key objectives will be to develop robust and scalable cell therapy bioprocesses and transfer these processes to contract manufacturing partners.

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  • Senior Scientist, Process Development

    As our lead programs advance into clinical development in 2019, Sigilon is looking for experienced process development scientists to join the team responsible for enhancing and evolving the manufacturing process for Sigilon’s encapsulated allogeneic cell therapy platform. Key objectives will be to develop robust and scalable cell therapy bioprocesses and transfer these processes to contract manufacturing partners.

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  • Sr. Associate Scientist, Analytical Chemistry

    The Sr. Associate Scientist, Analytical Chemistry will be responsible for running and developing methods to characterize small molecules, polymers, and formulated mixtures with both established and novel techniques.

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  • Vice President, Clinical Operations

    The Head of Clinical Operations is responsible for providing operational leadership for the successful initiation of clinical stage programs at Sigilon Therapeutics. The incumbent ensures that clinical stage projects achieve program objectives within established cost and timelines and provides direction and management oversight to external partners and vendors. This is an exciting opportunity to step into a newly created role reporting directly into Sigilon’s Chief Medical Officer (CMO).

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  • Vice President, Head of Regulatory Affairs

    The Head of Regulatory Affairs will be the senior regulatory strategist supporting Sigilon’s assets entry into clinical trials by leading, developing and implement regulatory plans to meet company goals and objectives. This is an exciting opportunity to step into a newly created role reporting directly into Sigilon’s Chief Medical Officer.

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  • Vice President, Platform Innovation and Biology

     

    As our lead programs advance into clinical development in 2019, the new VP of Platform Innovation and Biology will chart a course to enhance and evolve the SLTx platform by leading a team dedicated to applying state-of-the art molecular, cell biology, and immunology techniques to enable the next generation of encapsulated allogeneic cell therapies. Overall goals are to increase the breadth of therapeutic opportunities which Sigilon will pursue across several key dimensions that will include: a) targeted (local) protein delivery (e.g. CNS or eye); b) programmed and regulated protein expression (applying synthetic biology approaches); c) further enhancing durability of cell-based therapies; d) achieving higher levels of protein expression and secretion from engineered cells.

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Why work at Sigilon Therapeutics?

We provide a competitive salary and benefits package to our employees. Benefits include: a 401K plan, paid time off, health and dental insurance. We want our employees to love their work environment and enjoy working with their colleagues.

Team SigilonTX, June 2018

 

Team SigilonTX, June 2017