We are seeking versatile scientists to help us create immune privileged products that address unmet clinical needs.


  • We look for employees who are intellectually curious, willing to ask questions and take measured risks. When an employee joins Sigilon Therapeutics, they become part of the Sigilon Therapeutics family.

  • The ability for prospective employees to fit within the Sigilon Therapeutics culture is a critical consideration.


Sigilon Therapeutics is a multidisciplinary biotechnology company which specializes in creating immune privileged products to address unmet clinical needs.

Sigilon Therapeutics’s technology has the ability to completely transform how we treat patients with chronic diseases. Originated from Robert Langer and Daniel Anderson’s laboratories of MIT and was patented and published in three seminal reports in Nature Materials, Nature Biotechnology, and Nature Medicine in 2015 and 2016. The company is based in Cambridge, MA and is funded by Flagship Pioneering. Now is the time to get in on the ground floor of a fast growing company with a very interactive and open culture.

Please forward your application via email to careers@sigilon.com

    Current Openings

  • Biomedical Process Design Engineer

    Development and scale-up of cell-loaded hydrogel microsphere production process, integration of imaging inspection system into manufacturing process and more.

    learn more  

  • Director of Business Development

    Sigilon Therapeutics is searching for an energized candidate to play a key role in business development strategy and execution within a fast growing, highly innovative biotechnology company in Cambridge, MA. The successful candidate will have a good understanding of therapeutic discovery and development and the formation and execution of strategic partnerships.

    learn more  

  • Director of Islet Cell Biology

    Sigilon Therapeutics is searching for an energized candidate to help develop and execute on a program focused on allogeneic stem-cell derived pancreatic islet cells for treatment of diabetes. We seek a senior level scientist who is an expert in islet cell biology to further the work on this important therapy. Expertise in beta cell differentiation from hESC or iPSC cells is a critical aspect of the position.

    learn more  

  • Lab Operations Manager

    Sigilon Therapeutics is searching for a high energy candidate to help oversee lab operations and purchasing for Sigilon Therapeutics. This role will work closely with cross-functional teams including biology, chemistry, and engineering. The ideal candidate will be a highly capable, self-directed individual who takes initiative.

    learn more  

  • Research Associate (Diabetes)

    • Tissue culture of primary cells and pluripotent stem cell lines
    • Stable transfection and selection of engineered cell lines
    • Experience with stem cell differentiation protocols, preferably in the diabetes area
    • Perform functional and viability cell-based assays
    • Molecular and cell biology techniques, including ELISA, western blot, Immunohistochemistry, FACS, and qPCR
    • Work in a matrixed environment to insure cell lines meet the needs of the in vivo and cell biology teams
    • With increasing independence, plan, design and execute of a series of experiments that provide the research findings necessary for the completion of an assigned project
    • Demonstrate understanding and application of relevant scientific literature to the design of experimental protocols
    • Participate in discussions on optimizing protocols, tools, programs and/or new methods for project advancement and make the approved changes
    • Make observations, evaluate data, interpret results and document in a well-maintained laboratory notebook
    • Present results of experiments and findings in multidisciplinary team meetings
    • Participate in the coordination of assigned research with other teams as necessary to ensure the completion of the team’s research projects
    • Comply with standard laboratory practices and company policies

    learn more  

  • Research Associate (in vivo)

    This individual will be responsible for performing in-vivo studies in rodents, requiring surgery, necropsy, blood and tissue collection for analysis.

    learn more  

  • Senior / Director of Cell Biology

    Create and oversee the Cell Biology Department at Sigilon Therapeutics

    learn more  

  • Senior Process Chemist

    This person will assist in the development of small molecules, polymers, and medical devices with both established and novel techniques. This role will require regular interaction with stake holders in many disciplines, and the presentation of written and oral summaries of progress to management. Sigilon Therapeutics operates with a typical hybrid of internal and external resources and maintains a safe laboratory environment.

    learn more  

  • Vice President, Islet Cell Therapy Research

    Sigilon Therapeutics is searching for an energized candidate to lead a new team of diabetes focused scientists to develop a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge islet cell technology.  This group would have primary responsibility for research and early development of an encapsulated allogeneic islet cell product. Initial emphasis will be on developing a robust, reproducible and scalable b-cell differentiation protocol as well as overseeing relevant pre-clinical experiments and development activities to include IND enabling studies; tech transfer to a CMO; etc. The team will have full access to all of Sigilon’s cell biology and encapsulation chemistry expertise along with substantial designated funds to enable a rapid pursuit of a very robust and competitive program.

    learn more  

Why work at Sigilon Therapeutics?

We provide a competitive salary and benefits package to our employees. Benefits include: a 401K plan, paid time off, health and dental insurance. We want our employees to love their work environment and enjoy working with their colleagues.

Team SigilonTX, June 2017