We are seeking versatile scientists to help us create immune privileged products that address unmet clinical needs.


  • We look for employees who are intellectually curious, willing to ask questions and take measured risks. When an employee joins Sigilon Therapeutics, they become part of the Sigilon Therapeutics family.

  • The ability for prospective employees to fit within the Sigilon Therapeutics culture is a critical consideration.


Sigilon Therapeutics is a multidisciplinary biotechnology company which specializes in creating immune privileged products to address unmet clinical needs.

Sigilon Therapeutics’s technology has the ability to completely transform how we treat patients with chronic diseases. Originated from Robert Langer and Daniel Anderson’s laboratories of MIT and was patented and published in three seminal reports in Nature Materials, Nature Biotechnology, and Nature Medicine in 2015 and 2016. The company is based in Cambridge, MA and is funded by Flagship Pioneering. Now is the time to get in on the ground floor of a fast growing company with a very interactive and open culture.

Please forward your application via email to careers@sigilon.com

    Current Openings

  • Assistant Controller/Senior Accounting Manager

    Sigilon Therapeutics, Inc. is searching for an energized, proactive, hard-working candidate to play a key role on the Finance team of this fast growing, highly innovative biotechnology company in Cambridge, MA. The successful candidate will have a good understanding of a broad range of accounting and finance areas and be a key contributor in further developing the finance function by playing a key role in new systems (ERP) implementation, developing accounting policies and procedures and lending finance support to our transformative collaboration agreement with our big pharma partner.

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  • Biomedical Process Design Engineer

    Development and scale-up of cell-loaded hydrogel microsphere production process, integration of imaging inspection system into manufacturing process and more.

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  • Director of Business Development

    Sigilon Therapeutics is searching for an energized candidate to play a key role in business development strategy and execution within a fast growing, highly innovative biotechnology company in Cambridge, MA. The successful candidate will have a good understanding of therapeutic discovery and development and the formation and execution of strategic partnerships.

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  • Director of Islet Cell Biology

    Sigilon Therapeutics is searching for an energized candidate to help develop and execute on a program focused on allogeneic stem-cell derived pancreatic islet cells for treatment of diabetes. We seek a senior level scientist who is an expert in islet cell biology to further the work on this important therapy. Expertise in beta cell differentiation from hESC or iPSC cells is a critical aspect of the position.

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  • Executive Assistant

    The successful candidate will be a seasoned administrative professional with experience in a rapidly growing start-up environment preferably in a biotechnology company.

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  • Project Manager/Senior Project Manager

    • Lead teams to drive projects to milestones as quickly as feasible
    • Insure teams are constantly focused on “killer” experiments rather than non-value driving experiments
    • Management of projects from the proposal stage through commercialization
    • Liaising directly with stakeholders to understand their needs and constraints
    • Estimating timeline, resource, budget and key technical risks for proposal preparation
    • Tracking technical and commercial progress and achievements
    • Working on multiple teams at one time
    • Direct oversight of identifying, assessing, prioritizing external vendors to conduct key components of R&D pipeline projects

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  • Research Associate (in vivo)

    This individual will be responsible for performing in-vivo studies in rodents, requiring surgery, necropsy, blood and tissue collection for analysis.

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  • Senior / Director of Cell Biology

    Create and oversee the Cell Biology Department at Sigilon Therapeutics

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  • Senior Process Chemist

    This person will assist in the development of small molecules, polymers, and medical devices with both established and novel techniques. This role will require regular interaction with stake holders in many disciplines, and the presentation of written and oral summaries of progress to management. Sigilon Therapeutics operates with a typical hybrid of internal and external resources and maintains a safe laboratory environment.

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  • Vice President, Islet Cell Therapy Research

    Sigilon Therapeutics is searching for an energized candidate to lead a new team of diabetes focused scientists to develop a novel therapeutic product for diabetes utilizing Sigilon’s Afibromer™ technology combined with leading edge islet cell technology.  This group would have primary responsibility for research and early development of an encapsulated allogeneic islet cell product. Initial emphasis will be on developing a robust, reproducible and scalable b-cell differentiation protocol as well as overseeing relevant pre-clinical experiments and development activities to include IND enabling studies; tech transfer to a CMO; etc. The team will have full access to all of Sigilon’s cell biology and encapsulation chemistry expertise along with substantial designated funds to enable a rapid pursuit of a very robust and competitive program.

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Why work at Sigilon Therapeutics?

We provide a competitive salary and benefits package to our employees. Benefits include: a 401K plan, paid time off, health and dental insurance. We want our employees to love their work environment and enjoy working with their colleagues.

Team SigilonTX, June 2017